Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment

PE Goines, P Ashwood - Neurotoxicology and teratology, 2013 - Elsevier
Autism spectrum disorders (ASD) are neurodevelopmental diseases that affect an alarming
number of individuals. The etiological basis of ASD is unclear, and evidence suggests it …

Prenatal stress and genetic risk: How prenatal stress interacts with genetics to alter risk for psychiatric illness

PW Abbott, SB Gumusoglu, J Bittle… - …, 2018 - Elsevier
Risk for neuropsychiatric disorders is complex and includes an individual's internal genetic
endowment and their environmental experiences and exposures. Embryonic development …

The role of IL-6 in neurodevelopment after prenatal stress

SB Gumusoglu, RS Fine, SJ Murray, JL Bittle… - Brain, behavior, and …, 2017 - Elsevier
Prenatal stress exposure is associated with adverse psychiatric outcomes, including autism
and ADHD, as well as locomotor and social inhibition and anxiety-like behaviors in animal …

Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes

CE Mordaunt, JM Jianu, BI Laufer, Y Zhu, H Hwang… - Genome medicine, 2020 - Springer
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with
complex heritability and higher prevalence in males. The neonatal epigenome has the …

Neural stem cells derived from primitive mesenchymal stem cells reversed disease symptoms and promoted neurogenesis in an experimental autoimmune …

C Brown, C McKee, S Halassy, S Kojan… - Stem Cell Research & …, 2021 - Springer
Background Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central
nervous system (CNS). MS affects millions of people and causes a great economic and …

Neurodevelopmental origins of bipolar disorder: iPSC models

KS O'Shea, MG McInnis - Molecular and Cellular Neuroscience, 2016 - Elsevier
Bipolar disorder (BP) is a chronic neuropsychiatric condition characterized by pathological
fluctuations in mood from mania to depression. Adoption, twin and family studies have …

[HTML][HTML] Effect of catalpol on behavior and neurodevelopment in an ADHD rat model

H Yuan, X Ni, M Zheng, X Han, Y Song, M Yu - Biomedicine & …, 2019 - Elsevier
Studies suggest that abnormal neurodevelopment of prefrontal striatal circuits is implicated
in the pathogenesis of attention deficit hyperactivity disorder (ADHD). In the present study …

Dysregulation of neurite outgrowth and cell migration in autism and other neurodevelopmental disorders

S Prem, JH Millonig, E DiCicco-Bloom - … Disorders: Employing iPSC …, 2020 - Springer
Despite decades of study, elucidation of the underlying etiology of complex developmental
disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ), intellectual …

Immunotherapy for depression: Recent insights and future targets

Y Bai, Y Cai, D Chang, D Li, X Huo, T Zhu - Pharmacology & Therapeutics, 2024 - Elsevier
Depression stands as a prominent contributor to global disability, entailing an elevated risk
of suicide. Substantial evidence supports the notion that immune dysregulation may play a …

Prenatal stress and inhibitory neuron systems: implications for neuropsychiatric disorders

R Fine, J Zhang, HE Stevens - Molecular psychiatry, 2014 - nature.com
Prenatal stress is a risk factor for several psychiatric disorders in which inhibitory neuron
pathology is implicated. A growing body of research demonstrates that inhibitory circuitry in …