Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …

MicroRNAs are small noncoding RNAs which regulate gene expressions at post-
transcriptional level by binding to the 3′-untranslated region of target messenger RNAs …

The programmed cell death (PCD) pathway removes functionally insignificant, infection-
prone, or potentially tumorigenic cells, underscoring its important role in maintaining the …

Background Hyperthermia is a promising treatment for human lung cancer, but recurrence of
the primary lesion is common, as the residual tumor becomes adapted to heat treatment and …

Clock genes, major regulators of circadian rhythm, are involved in tumor progression. We
have shown that clock genes basic helix-loop-helix (BHLH) transcription factors …

Increasing evidence indicates that long non‑coding RNAs (lncRNAs) play an important role
in multiple biological processes including cell growth, differentiation, proliferation and …

Background Osteosarcoma is the most common primary bone cancer in children and young
adults. It is highly aggressive and patients that present with metastasis have a poor …

It is now fully recognized that along with multiple physiological functions, angiogenesis is
also involved in the fundamental process and pathobiology of several disorders including …

Cancer-associated fibroblasts (CAFs) are known to play an important role in cancer
progression, but their effects on tumor cell dormancy and the underlying mechanisms …

Abstract Background MicroRNA-138 (miR-138) has been proven to be a tumor suppressor
gene in various types of tumors. However, the expression and the role of miR-138 in human …