The biology and function of fibroblasts in cancer

R Kalluri - Nature Reviews Cancer, 2016 - nature.com
Among all cells, fibroblasts could be considered the cockroaches of the human body. They
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …

Myofibroblasts: function, formation, and scope of molecular therapies for skin fibrosis

Y Tai, EL Woods, J Dally, D Kong, R Steadman… - Biomolecules, 2021 - mdpi.com
Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …

Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin

T Tabib, M Huang, N Morse, A Papazoglou… - Nature …, 2021 - nature.com
Skin and lung fibrosis in systemic sclerosis (SSc) is driven by myofibroblasts, alpha-smooth
muscle actin expressing cells. The number of myofibroblasts in SSc skin correlates with the …

Developmental pathways in the pathogenesis of lung fibrosis

D Chanda, E Otoupalova, SR Smith, T Volckaert… - Molecular aspects of …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

Regeneration of dermis: scarring and cells involved

AL Rippa, EP Kalabusheva, EA Vorotelyak - Cells, 2019 - mdpi.com
There are many studies on certain skin cell specifications and their contribution to wound
healing. In this review, we provide an overview of dermal cell heterogeneity and their …

Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing

CH Lim, Q Sun, K Ratti, SH Lee, Y Zheng… - Nature …, 2018 - nature.com
Mammalian wounds typically heal by fibrotic repair without hair follicle (HF) regeneration.
Fibrosis and regeneration are currently considered the opposite end of wound healing. This …

Myofibroblasts

B Hinz - Experimental eye research, 2016 - Elsevier
Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or
damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction …

FAP and FAPI-PET/CT in malignant and non-malignant diseases: a perfect symbiosis?

K Dendl, SA Koerber, C Kratochwil, J Cardinale… - Cancers, 2021 - mdpi.com
Simple Summary FAPI represents a novel class of radiotracers demonstrating promising
results in terms of a high uptake in concordance with low background noise in several …

Skin cell heterogeneity in development, wound healing, and cancer

E Rognoni, FM Watt - Trends in cell biology, 2018 - cell.com
Skin architecture and function depend on diverse populations of epidermal cells and dermal
fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in …