Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

Precise gene expression ensures proper stem and progenitor cell differentiation, lineage
commitment and organogenesis during mammalian development. ATP-dependent …

Pluripotent embryonic stem cells (ESC s) are characterized by distinct epigenetic features
including a relative enrichment of histone modifications related to active chromatin. Among …

Chromatin accessibility, a crucial component of genome regulation, has primarily been
studied in homogeneous and simple systems, such as isolated cell populations or early …

Myocardial infarction (MI) is accompanied by severe energy deprivation and extensive
epigenetic changes. However, how energy metabolism and chromatin modifications are …

Mammals have partially lost the extensive regenerative capabilities of some vertebrates,
possibly as a result of chromatin-remodeling mechanisms that enforce terminal …

Background Individuals affected with autism often suffer additional co-morbidities such as
intellectual disability. The genes contributing to autism cluster on a relatively limited number …

AT-rich interactive domain-containing proteins 1A and 1B (ARID1A and ARID1B) are
mutually exclusive subunits of the chromatin remodeler SWI/SNF. ARID1A is the most …

Precise regulation of chromatin architecture is vital to physiological processes including
hematopoiesis. ARID1A is a core component of the mammalian SWI/SNF complex, which is …

Stem cells are continuously challenged with the decision to either self-renew or adopt a new
fate. Self-renewal is regulated by a system of cellular memory, which must be bypassed for …