Antibiotic perturbations to the gut microbiome
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …
Bile acid metabolism and signaling, the microbiota, and metabolic disease
The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …
gastrointestinal tract contributes to host health through its role in producing energy or …
The microbiome, cancer, and cancer therapy
BA Helmink, MAW Khan, A Hermann… - Nature medicine, 2019 - nature.com
With the advent of next-generation sequencing, we have an unprecedented ability to study
tumor and host genomes as well as those of the vast array of microorganisms that exist …
tumor and host genomes as well as those of the vast array of microorganisms that exist …
Global chemical effects of the microbiome include new bile-acid conjugations
A mosaic of cross-phylum chemical interactions occurs between all metazoans and their
microbiomes. A number of molecular families that are known to be produced by the …
microbiomes. A number of molecular families that are known to be produced by the …
Effects of metformin on the gut microbiota in obesity and type 2 diabetes mellitus
Q Zhang, N Hu - Diabetes, Metabolic Syndrome and Obesity, 2020 - Taylor & Francis
Metformin is a first-line treatment for type 2 diabetes mellitus (T2DM); however, its underlying
mechanism is not fully understood. Gut microbiota affect the development and progression …
mechanism is not fully understood. Gut microbiota affect the development and progression …
Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome
The gastrointestinal tract (GIT) affects not only local diseases in the GIT but also various
systemic diseases. Factors that can affect the health and disease of both GIT and the human …
systemic diseases. Factors that can affect the health and disease of both GIT and the human …
Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids
The changing epidemiology of Clostridium difficile infection over the past decades presents
a significant challenge in the management of C. difficile associated diseases. The …
a significant challenge in the management of C. difficile associated diseases. The …
Bile acid-independent protection against Clostridioides difficile infection
Clostridioides difficile infections occur upon ecological/metabolic disruptions to the normal
colonic microbiota, commonly due to broad-spectrum antibiotic use. Metabolism of bile acids …
colonic microbiota, commonly due to broad-spectrum antibiotic use. Metabolism of bile acids …
Community ecology as a framework for human microbiome research
JA Gilbert, SV Lynch - Nature medicine, 2019 - nature.com
The field of human microbiome research has revealed the intimate co-association of
humans with diverse communities of microbes in various habitats in the human body, and …
humans with diverse communities of microbes in various habitats in the human body, and …
Probiotics for prevention of Clostridium difficile infection
There have been a number of advances in probiotics and our understanding of their role in
prevention of CDI, but a number of important safety and efficacy questions remain. An …
prevention of CDI, but a number of important safety and efficacy questions remain. An …