Tumors are composed of non-homogeneous cell populations exhibiting varying degrees of
genetic and functional heterogeneity. Cancer stem cells (CSCs) are capable of sustaining …

The cancer stem cell (CSC) model has been established as a cellular mechanism that
contributes to phenotypic and functional heterogeneity in diverse cancer types. Recent …

The differentiation of tumorigenic cancer stem cells into nontumorigenic cancer cells confers
heterogeneity to some cancers beyond that explained by clonal evolution or environmental …

The transcription factors STAT1 and STAT3 appear to play opposite roles in tumorigenesis.
While STAT3 promotes cell survival/proliferation, motility and immune tolerance and is …

Cellular programs coupled to cycles of epithelial–mesenchymal transitions (EMTs) play
critical roles during embryogenesis, as well as during tissue development, remodeling, and …

The last 15 years has seen an explosion of interest in the cancer stem cell (CSC). Although it
was initially believed that only a rare population of stem cells are able to undergo self …

The clustered homeobox proteins play crucial roles in development, hematopoiesis, and
leukemia, yet the targets they regulate and their mechanisms of action are poorly …

Mutations in the metabolic enzymes isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) are
frequently found in glioma, acute myeloid leukemia (AML), melanoma, thyroid cancer, and …

Retinol and vitamin A derivatives influence cell differentiation, proliferation, and apoptosis
and play an important physiologic role in a wide range of biological processes. Retinol is …

The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene
overexpression but is currently considered undruggable. We therefore investigated whether …