[HTML][HTML] On the path to predicting immune responses in the lung: modeling the pulmonary innate immune system at the air-liquid interface (ALI)

J Graf, M Trautmann-Rodriguez, S Sabnis… - European Journal of …, 2023 - Elsevier
Chronic respiratory diseases and infections are among the largest contributors to death
globally, many of which still have no cure, including chronic obstructive pulmonary disorder …

Advanced in vitro lung models for drug and toxicity screening: the promising role of induced pluripotent stem cells

A Moreira, M Müller, PF Costa, Y Kohl - Advanced Biology, 2022 - Wiley Online Library
The substantial socioeconomic burden of lung diseases, recently highlighted by the
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …

Lung organoids in smoking research: current advances and future promises

H Agraval, HW Chu - Biomolecules, 2022 - mdpi.com
Tobacco smoking has been established to contribute to the pathogenesis of various
respiratory diseases including chronic obstructive pulmonary disease (COPD), lung cancer …

[HTML][HTML] Additive manufacturing in respiratory sciences–Current applications and future prospects

S Bock, T Rades, J Rantanen, R Scherließ - Advanced Drug Delivery …, 2022 - Elsevier
Additive Manufacturing (AM) comprises a variety of techniques that enable fabrication of
customised objects with specific attributes. The versatility of AM procedures and constant …

Recreating chronic respiratory infections in vitro using physiologically relevant models

L Grassi, A Crabbé - European Respiratory Review, 2024 - publications.ersnet.org
Despite the need for effective treatments against chronic respiratory infections (often caused
by pathogenic biofilms), only a few new antimicrobials have been introduced to the market in …

Culture of vibrating microtome tissue slices as a 3D model in biomedical research

F Siwczak, C Hiller, H Pfannkuche… - Journal of biological …, 2023 - Springer
The basic idea behind the use of 3-dimensional (3D) tools in biomedical research is the
assumption that the structures under study will perform at the best in vitro if cultivated in an …

An In Vitro Microfluidic Alveolus Model to Study Lung Biomechanics

V Kumar, SK Madhurakkat Perikamana… - … in bioengineering and …, 2022 - frontiersin.org
The gas exchange units of the lung, the alveoli, are mechanically active and undergo cyclic
deformation during breathing. The epithelial cells that line the alveoli contribute to lung …

Predicting nanomaterials pulmonary toxicity in animals by cell culture models: Achievements and perspectives

E Di Ianni, NR Jacobsen, U Vogel… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Animal experiments are highly relevant models for the assessment of toxicological effects of
engineered nanomaterials (ENMs), due to lack of biomonitoring and epidemiological …

[HTML][HTML] Microfluidic strategies for biomimetic lung chip establishment and SARS-CoV2 study

H Wang, T Wen, W Zhu, K Li, X Gong, Z Li - Materials Today Bio, 2024 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), characterized by its high
fatality rate and contagious nature, has led to significant morbidity and mortality worldwide …

Organotypic lung tissue culture as a preclinical model to study host-influenza A viral infection: A case for repurposing of nafamostat mesylate

P Saglam-Metiner, E Yildiz-Ozturk, A Tetik-Vardarli… - Tissue and Cell, 2024 - Elsevier
Reliable and effective models for recapitulation of host-pathogen interactions are imperative
for the discovery of potential therapeutics. Ex vivo models can fulfill these requirements as …