Cellular reprogramming technology has created new opportunities in understanding human
disease, drug discovery, and regenerative medicine. While a combinatorial code was …

Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

Loss of neurons after brain injury and in neurodegenerative disease is often accompanied
by reactive gliosis and scarring, which are difficult to reverse with existing treatment …

Despite the widespread interest in direct neuronal reprogramming, the mechanisms
underpinning fate conversion remain largely unknown. Our study revealed a critical time …

Reactive astrocytes (RAs) have been reported to convert to multipotent neural stem cells
(NSCs) capable of neurosphere (NS) formation and multilineage differentiation in vitro …

In vivo induction of non-neuronal cells into neurons by transcription factors offers potential
therapeutic approaches for neural regeneration. Although generation of induced neuronal …

We have recently demonstrated that reactive glial cells can be directly reprogrammed into
functional neurons by a single neural transcription factor, NeuroD1. Here we report that a …

Reprogramming of somatic cells into neurons provides a new approach toward cell-based
therapy of neurodegenerative diseases. A major challenge for the translation of neuronal …

Glial cells can be in vivo reprogrammed into functional neurons in the adult CNS; however,
the process by which this reprogramming occurs is unclear. Here, we show that a distinct …

The possibility of directly converting non-neuronal cells into neurons in situ in the brain
would open therapeutic avenues aimed at repairing the brain after injury or degenerative …