Apoptotic cell death in disease—Current understanding of the NCCD 2023
I Vitale, F Pietrocola, E Guilbaud… - Cell Death & …, 2023 - nature.com
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
Interleukin-7 biology and its effects on immune cells: mediator of generation, differentiation, survival, and homeostasis
D Chen, TX Tang, H Deng, XP Yang… - Frontiers in …, 2021 - frontiersin.org
Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B
cells, remains one of the most extensively studied cytokines. It plays a vital role in health …
cells, remains one of the most extensively studied cytokines. It plays a vital role in health …
Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance
Defects in apoptosis can promote tumorigenesis and impair responses of malignant B cells
to chemotherapeutics. Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of …
to chemotherapeutics. Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of …
An essential role for the IL-2 receptor in Treg cell function
Regulatory T cells (Treg cells), which have abundant expression of the interleukin 2 receptor
(IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for …
(IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for …
Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development
Tissue regeneration is an orchestrated progression of cells from an immature state to a
mature one, conventionally represented as distinctive cell subsets. A continuum of …
mature one, conventionally represented as distinctive cell subsets. A continuum of …
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …
JAK inhibitors for atopic dermatitis: an update
H He, E Guttman-Yassky - American journal of clinical dermatology, 2019 - Springer
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. AD is driven
by barrier dysfunction and abnormal immune activation of T helper (Th) 2, Th22, and varying …
by barrier dysfunction and abnormal immune activation of T helper (Th) 2, Th22, and varying …
IL-7: comprehensive review
Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …
Type I cytokine receptors. It is produced by stromal cells and is required for development …
Regulatory T cells: mechanisms of differentiation and function
SZ Josefowicz, LF Lu… - Annual review of …, 2012 - annualreviews.org
The immune system has evolved to mount an effective defense against pathogens and to
minimize deleterious immune-mediated inflammation caused by commensal …
minimize deleterious immune-mediated inflammation caused by commensal …
Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer
B Wingelhofer, HA Neubauer, P Valent, X Han… - Leukemia, 2018 - nature.com
STAT3 and STAT5 proteins are oncogenic downstream mediators of the JAK–STAT
pathway. Deregulated STAT3 and STAT5 signaling promotes cancer cell proliferation and …
pathway. Deregulated STAT3 and STAT5 signaling promotes cancer cell proliferation and …