The protein data bank archive
Abstract Protein Data Bank is the single worldwide archive of experimentally determined
macromolecular structure data. Established in 1971 as the first open access data resource in …
macromolecular structure data. Established in 1971 as the first open access data resource in …
[PDF][PDF] The CCP4 suite: integrative software for macromolecular crystallography
The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective
with a mission to develop, test, distribute and promote software for macromolecular …
with a mission to develop, test, distribute and promote software for macromolecular …
[HTML][HTML] Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of …
2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of …
Secreted pectin monooxygenases drive plant infection by pathogenic oomycetes
F Sabbadin, S Urresti, B Henrissat, AO Avrova… - Science, 2021 - science.org
The oomycete Phytophthora infestans is a damaging crop pathogen and a model organism
to study plant-pathogen interactions. We report the discovery of a family of copper …
to study plant-pathogen interactions. We report the discovery of a family of copper …
A single sulfatase is required to access colonic mucin by a gut bacterium
Humans have co-evolved with a dense community of microbial symbionts that inhabit the
lower intestine. In the colon, secreted mucus creates a barrier that separates these …
lower intestine. In the colon, secreted mucus creates a barrier that separates these …
[HTML][HTML] The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis
Anthocyanins are ubiquitous plant pigments used in a variety of technological applications.
Yet, after over a century of research, the penultimate biosynthetic step to anthocyanidins …
Yet, after over a century of research, the penultimate biosynthetic step to anthocyanidins …
[HTML][HTML] Structural basis of nirmatrelvir and ensitrelvir activity against naturally occurring polymorphisms of the SARS-CoV-2 main protease
GD Noske, E de Souza Silva, MO de Godoy… - Journal of Biological …, 2023 - ASBMB
SARS-CoV-2 is the causative agent of COVID-19. The main viral protease (M pro) is an
attractive target for antivirals. The clinically approved drug nirmatrelvir and the clinical …
attractive target for antivirals. The clinically approved drug nirmatrelvir and the clinical …
[HTML][HTML] In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease
Abstract γ-Amino acids can play important roles in the biological activities of natural
products; however, the ribosomal incorporation of γ-amino acids into peptides is …
products; however, the ribosomal incorporation of γ-amino acids into peptides is …
Posttranslational modification of microtubules by the MATCAP detyrosinase
The detyrosination-tyrosination cycle involves the removal and religation of the C-terminal
tyrosine of α-tubulin and is implicated in cognitive, cardiac, and mitotic defects. The …
tyrosine of α-tubulin and is implicated in cognitive, cardiac, and mitotic defects. The …
Structural basis of omega-3 fatty acid transport across the blood–brain barrier
Docosahexaenoic acid is an omega-3 fatty acid that is essential for neurological
development and function, and it is supplied to the brain and eyes predominantly from …
development and function, and it is supplied to the brain and eyes predominantly from …