Accumulating evidence demonstrates that metabolic changes in the brain associated with
neuroinflammation, oxidative stress, and mitochondrial dysfunction play an important role in …

Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …

The neurodevelopmental and dopamine hypotheses are leading theories of the
pathoetiology of schizophrenia, but they were developed in isolation. However, since they …

In this review article we have consolidated the imaging literature of patients with
schizophrenia across the full spectrum of modalities in radiology including computed …

Glutamatergic excitotoxicity is hypothesised to underlie synaptic loss in schizophrenia
pathogenesis, but it is unknown whether synaptic markers are related to glutamatergic …

Background Impaired brain metabolism may be central to schizophrenia pathophysiology,
but the magnitude and consistency of metabolic dysfunction is unknown. Methods We …

Background Magnetic resonance spectroscopy studies measuring brain glutamate
separately from glutamine are helping elucidate schizophrenia pathophysiology. An …

There has been increasing interest in the role of mitochondrial dysfunction in the
pathophysiology of schizophrenia. Mitochondrial complex one (MCI) dysfunction may …

Background Brain metabolite abnormalities measured with magnetic resonance
spectroscopy (MRS) provide insight into pathological processes in schizophrenia. Prior meta …

With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …