Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Abstract Caspase‐3, a cysteine‐aspartic acid protease, has recently attracted much
attention because of its incredible roles in tissue differentiation, regeneration, and neural …

The triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial innate immune
receptor associated with a lethal form of early, progressive dementia, Nasu-Hakola disease …

Recovery after stroke is a multicellular process encompassing neurons, resident immune
cells, and brain-invading cells. Stroke alters the gut microbiome, which in turn has …

The final stage of brain development is associated with the generation and maturation of
neuronal synapses. However, the same period is also associated with a peak in synapse …

Maturation of neuronal circuits requires selective elimination of synaptic connections.
Although neuron-intrinsic mechanisms are important in this process, it is increasingly …

The concept of central nervous system (CNS) inflammation has evolved over the last
decades. Neuroinflammation is the response of reactive CNS components to altered …

Schizophrenia is a debilitating disorder that typically begins in adolescence and is
characterized by perceptual abnormalities, delusions, cognitive and behavioural …

Chemotherapeutic agents cause many short and long term toxic side effects to peripheral
nervous system (PNS) that drastically alter quality of life. Chemotherapy-induced peripheral …

Elimination of dead or live cells take place in both a healthy and diseased central nervous
system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance …