The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors
G Trujillo-de Santiago, BG Flores-Garza… - Materials, 2019 - mdpi.com
The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …
understanding of cancer etiology and development of better anticancer therapies—is highly …
Intracellular and microenvironmental regulation of mitochondrial membrane potential in cancer cells
Cancer cells have an abnormally high mitochondrial membrane potential (ΔΨm), which is
associated with enhanced invasive properties in vitro and increased metastases in vivo. The …
associated with enhanced invasive properties in vitro and increased metastases in vivo. The …
Oxygen control: the often overlooked but essential piece to create better in vitro systems
V Palacio-Castañeda, N Velthuijs, S Le Gac… - Lab on a Chip, 2022 - pubs.rsc.org
Variations in oxygen levels play key roles in numerous physiological and pathological
processes, but are often not properly controlled in in vitro models, introducing a significant …
processes, but are often not properly controlled in in vitro models, introducing a significant …
Microfluidic-Based Oxygen (O2) Sensors for On-Chip Monitoring of Cell, Tissue and Organ Metabolism
Oxygen (O2) quantification is essential for assessing cell metabolism, and its consumption in
cell culture is an important indicator of cell viability. Recent advances in microfluidics have …
cell culture is an important indicator of cell viability. Recent advances in microfluidics have …
Evaluating CAR‐T cell therapy in a hypoxic 3D tumor model
Despite its revolutionary success in hematological malignancies, chimeric antigen receptor
T (CAR‐T) cell therapy faces disappointing clinical results in solid tumors. The poor efficacy …
T (CAR‐T) cell therapy faces disappointing clinical results in solid tumors. The poor efficacy …
Microfluidics in vascular biology research: a critical review for engineers, biologists, and clinicians
G Simitian, M Virumbrales-Muñoz… - Lab on a Chip, 2022 - pubs.rsc.org
Neovascularization, the formation of new blood vessels, has received much research
attention due to its implications for physiological processes and diseases. Most studies …
attention due to its implications for physiological processes and diseases. Most studies …
Fluorescent nano-and microparticles for sensing cellular microenvironment: past, present and future applications
The tumor microenvironment (TME) demonstrates distinct hallmarks, including acidosis,
hypoxia, reactive oxygen species (ROS) generation, and altered ion fluxes, which are crucial …
hypoxia, reactive oxygen species (ROS) generation, and altered ion fluxes, which are crucial …
Integrated biosensors for monitoring microphysiological systems
Microphysiological systems (MPSs), also known as organ-on-a-chip models, aim to
recapitulate the functional components of human tissues or organs in vitro. Over the last …
recapitulate the functional components of human tissues or organs in vitro. Over the last …
A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient
After a myocardial infarction, the boundary between the injured, hypoxic tissue and the
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …
[HTML][HTML] On-chip recapitulation of the tumor microenvironment: A decade of progress
One of the hurdles to the development of new anticancer therapies is the lack of in vitro
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …