Simple Summary Cancer immunotherapy is currently focused mainly on the enhancement of
the effector function of T cells. However, dendritic cells (DCs) are needed to prime T cells …

FLT3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is
important for the normal development of stem cells and the immune system. The ligand for …

Normal haematopoietic cells use complex systems to control proliferation, differentiation and
cell death. The control of proliferation is, in part, accomplished through the ligand-induced …

The ligand for the receptor tyrosine kinase fms-like tyrosine kinase 3 (flt3), also referred to as
fetal liver kinase-2 (flk-2), has an important role in hematopoiesis. The flt3 ligand (flt3L) is a …

Cytotoxic T lymphocytes and natural killer cells are essential effectors of anti-tumor immune
responses in vivo. Dendritic cells (DC)'prime'tumor antigen-specific cytotoxic T lymphocytes; …

HEMATOPOIESIS IS A life-long process responsible for replenishing both hematopoietic
progenitor cells and mature blood cells from a pool of pluripotent, long-term reconstituting …

Both granulocyte-macrophage colony-stimulating factor (GM-CSF) and flt3-ligand (FL)
induce the development of dendritic cells (DCs). To compare the functional properties of …

Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in
immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their …

Bone marrow-derived dendritic cells (BmDC) are potent APC and can promote antitumor
immunity in mice when pulsed with tumor Ag. This study aimed to define the culture …

An ineffective tumor-specific immune response from inadequate/incompetent antigen
presentation could contribute to the failure in tumor control and its dissemination. Dendritic …