Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated
protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are …

The HOX genes are a highly conserved group of transcription factors that have key roles in
early development, but which are also highly expressed in most cancers. Many studies have …

Some polypeptide N-acetyl-galactosaminyltransferases (GALNTs) are associated with
cancer, but their function in organ-specific metastasis remains unclear. Here, we report that …

The deregulation of polypeptide N-acetyl-galactosaminyltransferases (GALNTs) contributes
to several cancers, but their roles in lung cancer remain unclear. In this study, we have …

HOX family transcription factors belong to a highly conserved subgroup of the homeobox
superfamily that determines cellular fates in embryonic morphogenesis and the …

Members of the polypeptide N-acetylgalactosaminyltransferase (GALNT) family function as
the initiating enzymes that catalyze mucin-type O-glycosylation of proteins, and their …

Drug repositioning is an attractive alternative to conventional drug development when new
beneficial effects of old drugs are clinically validated because pharmacokinetic and safety …

Despite the continual discovery of promising new cancer targets, drug discovery is often
hampered by the poor druggability of these targets. As such, repurposing FDA-approved …

Simple Summary The inhibition of angiogenesis, relying on the use of drugs targeting the
VEGF signaling pathway, has become one of the main strategies for cancer treatment …

Protein glycosylation perturbations are implicated in a variety of diseases, including cancer.
Aberrant glycosylation in cancer is frequently attributed to altered expression of polypeptide …