Bordetella pertussis causes whooping cough, a severe respiratory tract infection in infants
and children, and also infects adults. Studies in murine models have shown that innate …

Pertussis toxin and adenylate cyclase toxin are two important virulence factors of Bordetella
pertussis, the bacterial cause of the respiratory disease pertussis or whooping cough. In …

Monocyte chemoattractant protein (MCP)-1 plays a critical role in innate immunity by
directing the migration of monocytes into inflammatory sites. Recent data indicated a …

Pertussis toxin, produced and secreted by the whooping cough agent Bordetella pertussis,
is one of the most complex soluble bacterial proteins. It is actively secreted through the B …

Bordetella pertussis exploits extracellular and intracellular niches in the respiratory tract and
a variety of immune evasion strategies to prolong its survival in the host. This article reviews …

Pertussis toxin (PT) has been widely used to facilitate the induction of experimental
autoimmune encephalomyelitis (EAE) in rodents. It has been suggested that this microbial …

Pertussis, caused by respiratory tract infection with the bacterial pathogen Bordetella
pertussis, has long been considered to be a toxin-mediated disease. Bacteria adhere and …

The nasal route offers a promising opportunity for the delivery of vaccines. This review
analyses the opportunities and novel delivery strategies based on particulate systems for the …

Current paediatric immunization programmes include too many injections in the first months
of life. Oral or nasal vaccine delivery eliminates the requirement for needles and can induce …

IL-1 is a pro-inflammatory cytokine that plays an important role in inflammation and host
responses to infection. We have previously shown that imbalances in the IL-1 and IL-1R …