Zinc is an essential trace element, and anemia is the most common blood disorder. The
association of zinc with anemia may be divided into three major forms:(1) zinc deficiency …

Maintaining the correct number of healthy red blood cells (RBCs) is critical for proper
oxygenation of tissues throughout the body. Therefore, RBC homeostasis is a tightly …

TMPRSS6 is a serine protease highly expressed in the liver. Its role in iron regulation was
first reported in 2008 when mutations in TMPRSS6 were shown to be the cause of iron …

Iron participates in myriad processes necessary to sustain life. During the past decades,
great efforts have been made to understand iron regulation and function in health and …

Red blood cells (RBC) are specifically differentiated to transport oxygen and carbon dioxide
in the blood and they lack most organelles, including mitochondria. The autoxidation of …

Eryptosis is a regulated cell death (RCD) of mature erythrocytes initially described as a
counterpart of apoptosis for enucleated cells. However, over the recent years, a growing …

Erythropoiesis is a complex process driving the production of red blood cells. During
homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by …

Controlled release of promoter-proximal paused RNA polymerase II (RNA Pol II) is crucial
for gene regulation. However, studying RNA Pol II pausing is challenging, as pause-release …

Anemia is the most common hematologic abnormality identified in children and represents a
major global health problem. A delay in diagnosis and treatment might place patients with …

During the last years, several strategies have been made to obtain mature erythrocytes or
red blood cells (RBC) from the bone marrow or umbilical cord blood (UCB). However, UCB …