Brain hemispheres are connected by commissural structures, which consist of white matter
fiber tracts that spread excitatory stimuli to various regions of the cortex. This allows an …

After its publication in 1999 as a DNA-binding and SMAD-binding transcription factor (TF)
that co-determines cell fate in amphibian embryos, ZEB2 was from 2003 studied by …

The human brain has undergone rapid expansion since humans diverged from other great
apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use …

Purpose Mowat–Wilson syndrome (MWS) is a rare intellectual disability/multiple congenital
anomalies syndrome caused by heterozygous mutation of the ZEB2 gene. It is generally …

Congenital heart disease (CHD) is the most common birth anomaly, affecting almost 1% of
infants. Neurodevelopmental delay is the most common extracardiac feature in people with …

Mowat-Wilson syndrome (MOWS) is a rare congenital disease caused by haploinsufficiency
of ZEB2, encoding a transcription factor required for neurodevelopment. MOWS is …

Schizophrenia (SZ) is a pervasive neurodevelopmental disorder that entails social and
cognitive deficits, including marked language problems. Its complex multifactorial …

Cerebral visual impairments (CVIs) is an umbrella term that categorizes miscellaneous
visual defects with parallel genetic brain disorders. While the manifestations of CVIs are …

Mowat-Wilson syndrome (MWS) is characterized by distinctive facial features (widely spaced
eyes, broad eyebrows with a medial flare, low-hanging columella, prominent or pointed chin …

Neural connectivity requires neuronal differentiation, axon growth, and precise target
innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the …