Immunoglobulin germline gene variation and its impact on human disease
Immunoglobulins (Ig) play an important role in the immune system both when expressed as
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …
Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires
The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
Several studies have shown that the pre-vaccination immune state is associated with the
antibody response to vaccination. However, the generalizability and mechanisms that …
antibody response to vaccination. However, the generalizability and mechanisms that …
CoV-AbDab: the coronavirus antibody database
MIJ Raybould, A Kovaltsuk, C Marks… - Bioinformatics, 2021 - academic.oup.com
Motivation The emergence of a novel strain of betacoronavirus, SARS-CoV-2, has led to a
pandemic that has been associated with over 700 000 deaths as of August 5, 2020 …
pandemic that has been associated with over 700 000 deaths as of August 5, 2020 …
Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2
B cells are critical for the production of antibodies and protective immunity to viruses. Here
we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS …
we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS …
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19
Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe
COVID-19. However, the immune signatures associated with immunopathology are poorly …
COVID-19. However, the immune signatures associated with immunopathology are poorly …
An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans
SF Andrews, LY Cominsky, GD Shimberg… - Science Translational …, 2023 - science.org
Current yearly seasonal influenza vaccines primarily induce an antibody response directed
against the immunodominant but continually diversifying hemagglutinin (HA) head region …
against the immunodominant but continually diversifying hemagglutinin (HA) head region …
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies
P Pushparaj, A Nicoletto, DJ Sheward, H Das… - Immunity, 2023 - cell.com
The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high
levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which …
levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which …
Host factors impact vaccine efficacy: implications for seasonal and universal influenza vaccine programs
Influenza is a global public health problem. Current seasonal influenza vaccines have highly
variable efficacy, and thus attempts to develop broadly protective universal influenza …
variable efficacy, and thus attempts to develop broadly protective universal influenza …
Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus
M Sangesland, AT de la Peña, S Boyoglu-Barnum… - Immunity, 2022 - cell.com
Human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin stalk of group 1
influenza A viruses (IAVs) are biased for IGHV1-69 alleles that use phenylalanine (F54) but …
influenza A viruses (IAVs) are biased for IGHV1-69 alleles that use phenylalanine (F54) but …