Great advances in immune checkpoint blockade have resulted in a paradigm shift in patients
with lung cancer. Immune-checkpoint inhibitor (ICI) treatment, either as monotherapy or …

Wnt/β-catenin signaling is a highly conserved pathway that regulates cell proliferation,
differentiation, apoptosis, stem cell self-renewal, tissue homeostasis, and wound healing …

Immunotherapy with checkpoint inhibitors has greatly prolonged the overall survival of
cancer patients in melanoma and many other cancer types. However, only a subset of …

Despite the dramatic antitumor efficiency of certain immune checkpoint inhibitors,
immunotherapy has met a bottleneck regarding the response rate and resistance in cancer …

Wnt proteins comprise a large family of highly conserved glycoproteins known for their role
in development, cell fate specification, tissue regeneration, and tissue homeostasis …

Triple-negative breast cancer (TNBC) is not as prevalent as hormone receptor or HER2-
positive breast cancers and all receptor tests come back negative. More importantly, the …

Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse
mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in …

Polarization of immune cells is commonly observed in host responses associated with
microbial immunity, inflammation, tumorigenesis, and tissue repair and fibrosis. In this …

Background Th subsets particularly T helper 17 and regulatory T cells play a critical role in
immune balance in colonic mucosa of Inflammatory Bowel Disease. Recent studies have …

Dendritic cells (DCs) control the strength and quality of antigen-specific adaptive immune
responses. This is critical for launching a robust immunity against invading pathogens while …