The 2–5 A system: Modulation of viral and cellular processes through acceleration of RNA degradation

MR Player, PF Torrence - Pharmacology & therapeutics, 1998 - Elsevier
The 2–5A system is an RNA degradation pathway that can be induced by the interferons
(IFNs). Treatment of cells with IFN activates genes encoding several double-stranded RNA …

Dissecting the mode of action of a neuronal growth factor

S Halegoua, RC Armstrong, NE Kremer - Neuronal Growth Factors, 1991 - Springer
The neuronal growth factors nerve growth-factor (NGF) and fibroblast growth factor (FGF)
play important roles in the development of both the peripheral and central nervous systems …

Interferon suppresses sympathetic neuronal cell death caused by nerve growth factor deprivation

JY Chang, DP Martin… - Journal of …, 1990 - Wiley Online Library
Cultured rat sympathetic neurons die within 48 h after being deprived of nerve growth factor.
Addition of interferons (IFN‐α/β or IFN‐γ) prevented the cell death in a dose‐dependent …

Interferon-induced proteins are elevated in blood samples of patients with chemically or virally induced chronic fatigue syndrome

A Vojdani, CW Lapp - Immunopharmacology and …, 1999 - Taylor & Francis
Abstract Overlapping symptomatologies between Chronic Fatigue Syndrome (CFS) and
Chemical Sensitivity have been observed by different investigators. Therefore, it is of great …

IFN-γ facilitates NGF-induced neuronal differentiation in PC12 cells

T Improta, AM Salvatore, A Di Luzio, G Romeo… - Experimental cell …, 1988 - Elsevier
Natural or recombinant murine interferon-γ causes a reversible arrest of proliferation of
PC12 cells. Treatment with other antimitotics (AraC, colchicine, mitomycin C, hydroxy-urea) …

Transforming growth factor β1 enhances expression of 50 kDa protein related to 2′‐5′ oligoadenylate synthetase in human sperm cells

RK Naz, R Kumar - Journal of cellular physiology, 1991 - Wiley Online Library
Human cellular polypeptide factors, namely interferon‐α, interferon‐γ, transforming growth
factor (TGF)‐α, and TGF‐β, were analyzed for their effect on motility of human sperm cells …

Regulation of 2′, 5′-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor

MA Garcia-Blanco, P Lengyel, E Morrison… - … and cellular biology, 1989 - Taylor & Francis
In murine BALB/c 3T3 cell cultures, either beta interferon or platelet-derived growth factor
(PDGF) enhanced expression of the 2′, 5′-oligoadenylate synthetase mRNA and protein …

Enzyme assays for synthesis and degradation of 2-5As and other 2′-5′ oligonucleotides

JB Poulsen, KH Kjær, J Justesen, PM Martensen - BMC biochemistry, 2015 - Springer
Abstract Background The 5′-triphosphorylated, 2′-5′-linked oligoadenylate
polyribonucleotides (2-5As) are central to the interferon-induced antiviral 2-5A system. The 2 …

Activation of the interferon system during myogenesis in vitro

M Birnbaum, B Trink, A Shainberg, S Salzberg - Differentiation, 1990 - Wiley Online Library
Differentiation of skeletal muscle involves withdrawal of myoblasts from cell replication,
fusion to form multinucleated myotubes, coordinate appearance of a variety of muscle …

2′, 5′-Oligoadenylate synthetase expression is induced in response to heat shock.

S Chousterman, MK Chelbi-Alix, MN Thang - Journal of Biological …, 1987 - ASBMB
Hyperthermia (45 degrees C) induced the synthesis of a characteristic heat-shock protein of
70,000 daltons (70 hsp) in Madin-Darby bovine kidney (MDBK) cells. In addition …