Generation of reactive oxygen species and related oxidants is an inevitable consequence of
life. Proteins are major targets for oxidation reactions, because of their rapid reaction rates …

The identification of plasma proteins that systematically change with age and, independent
of chronological age, predict accelerated decline of health is an expanding area of research …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Senescence and epigenetic alterations stand out as two well-characterized hallmarks of
aging. When cells become senescent, they cease proliferation and release inflammatory …

The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or
glycation of cellular proteins result in the generation and accumulation of advanced …

Mitochondria are essential for cellular functions such as metabolism and apoptosis. They
dynamically adapt to the changing environmental demands by adjusting their protein …

Posttranslational protein modification by lysine acylation is an emerging mechanism of
cellular regulation and fine-tunes metabolic processes to environmental changes. In this …

Aging-related diseases such as cancer can be traced to the accumulation of molecular
disorder including increased DNA mutations and epigenetic drift. We provide a …

Parkinson's disease (PD) is a still incurable neurodegenerative disorder with a highly
complex etiology. While about 10% of cases are associated with single-gene mutations, the …

Aging has become one of the fastest-growing research topics in biology. However, exactly
how the aging process occurs remains unknown. Epigenetics plays a significant role, and …