[HTML][HTML] Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put
JA Simon, RE Kingston - Molecular cell, 2013 - cell.com
Chromatin modification by Polycomb proteins provides an essential strategy for gene
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …
The general transcription machinery and general cofactors
MC Thomas, CM Chiang - Critical reviews in biochemistry and …, 2006 - Taylor & Francis
In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …
RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3
L Tavares, E Dimitrova, D Oxley, J Webster, R Poot… - Cell, 2012 - cell.com
Summary Polycomb-repressive complex 1 (PRC1) has a central role in the regulation of
heritable gene silencing during differentiation and development. PRC1 recruitment is …
heritable gene silencing during differentiation and development. PRC1 recruitment is …
Histones: annotating chromatin
EI Campos, D Reinberg - Annual review of genetics, 2009 - annualreviews.org
Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …
structured and maneuvered to elicit cellular processes, including transcription, cell division …
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation
M de Napoles, JE Mermoud, R Wakao, YA Tang… - Developmental cell, 2004 - cell.com
Abstract In many higher organisms, 5%–15% of histone H2A is ubiquitylated at lysine 119
(uH2A). The function of this modification and the factors involved in its establishment …
(uH2A). The function of this modification and the factors involved in its establishment …
Chromatin compaction by a polycomb group protein complex
NJ Francis, RE Kingston, CL Woodcock - Science, 2004 - science.org
Polycomb group proteins preserve body patterning through development by maintaining
transcriptional silencing of homeotic genes. A long-standing hypothesis is that silencing …
transcriptional silencing of homeotic genes. A long-standing hypothesis is that silencing …
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination
How polycomb group proteins repress gene expression in vivo is not known. While histone-
modifying activities of the polycomb repressive complexes (PRCs) have been studied …
modifying activities of the polycomb repressive complexes (PRCs) have been studied …
Polycomb silencing mechanisms and the management of genomic programmes
YB Schwartz, V Pirrotta - Nature Reviews Genetics, 2007 - nature.com
Polycomb group complexes, which are known to regulate homeotic genes, have now been
found to control hundreds of other genes in mammals and insects. First believed to …
found to control hundreds of other genes in mammals and insects. First believed to …
PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency
The Polycomb repressive system plays a fundamental role in controlling gene expression
during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 …
during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 …
Transcriptional silencing by polycomb-group proteins
U Grossniklaus, R Paro - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Polycomb-group (PcG) genes encode chromatin proteins involved in stable and heritable
transcriptional silencing. PcG proteins participate in distinct multimeric complexes that …
transcriptional silencing. PcG proteins participate in distinct multimeric complexes that …