Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an
insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor …

Abstract DNMT1 (DNA methyltransferase 1) is the predominant member of the DNMT family
and the most abundant DNMT in various cell types. It functions as a maintenance DNMT and …

The maintenance of epigenetic characteristics is essential for the normal growth and
development of organisms. The maintenance of DNA methylation is an important way to …

DNA methylation is a broadly-investigated epigenetic modification that has been considered
as a heritable and reversible change. Previous findings have indicated that DNA methylation …

Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer's
Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect …

The balance of excitation and inhibition is essential for cortical information processing,
relying on the tight orchestration of the underlying subcellular processes. Dynamic …

Tonicity-responsive enhancer binding protein (TonEBP or NFAT5) is a regulator of cellular
adaptation to hypertonicity, macrophage activation and T-cell development. Here we report …