1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

Spirooxindoles are important synthetic targets possessing extended biological activity and
drug discovery applications. This review focuses on the various strategies for the …

Isatins are well‐known carbonyl electrophiles which allow a vast number of reactions
initiated by nucleophilic attack on the C3 carbonyl group when used as starting materials …

Azomethine ylides are nitrogen-based three-atom components commonly used in [3+ 2]-
cycloaddition reactions with various unsaturated 2π-electron components. These reactions …

In this study, the Monte Carlo method was applied for quantitative structure-activity
relationship of novel steroidal spiro-oxindoles as potent antiproliferative inhibitors against …

A series of spiro [pyrrolidin-2, 3′-oxindoles] has been synthesized by exo-selective 1, 3-
dipolar cycloaddition reaction of a stabilized azomethine ylide, generated in situ by thermal …

Synthesis of heterocyclic compounds based on isatin through 1, 3- dipolar cycloaddition
reactions Page 1 Reviews and Accounts ARKIVOC 2012 (i) 277-320 Page 277 ©ARKAT-USA …

Because of their definite or potential biological and pharmaceutical activities, spirooxindole
heterocycles have been widely studied, and there has occurred a research boom on routes …

A series of new spiro-heterocycles engrafted spirooxindole/pyrrolidine/thiochromene
scaffolds was synthesized by the three-component 1, 3-dipolar cycloaddition reactions in a …

A series of novel dispirooxindole derivatives, 3-acetyl-5-phenyl-pyrrolo (spiro-[2.3′]-1′-
benzyl-oxindole)-spiro-[4.3 ″]-1 ″-benzyl-oxindoles, were synthesized via 1, 3-dipolar …