Restoration of peripheral blood natural killer and B cell levels in patients affected by rheumatoid and psoriatic arthritis during etanercept treatment

P Conigliaro, P Triggianese, C Perricone… - Clinical & …, 2014 - academic.oup.com
Etanercept (ETN) is an anti-tumour necrosis factor (TNF)-α agent used in rheumatoid arthritis
(RA) and psoriatic arthritis (PsA). Few studies focused on the effects of anti-TNF-α on …

Systemic and local increase of granulysin expression in cytotoxic lymphocytes in severe psoriasis

M Vičić, M Kaštelan… - Acta dermato …, 2019 - unirepository.svkri.uniri.hr
Psoriasis is a chronic inflammatory skin disease that affects around 2% of the population (1).
Although the disease may present with different clinical features, the most common …

Evidence of IL-17 producing innate lymphoid cells in peripheral blood from patients with enteropathic spondyloarthritis

P Triggianese, P Conigliaro, MS Chimenti… - Clinical and …, 2016 - art.torvergata.it
Objective Both the innate and the adaptive immune responses contribute to the onset of
chronic inflammation in spondyloarthritis (SpA). The association between SpA and …

What rheumatologists need to know about innate lymphocytes

MA Exley, GC Tsokos, KHG Mills, D Elewaut… - Nature Reviews …, 2016 - nature.com
Many rheumatic diseases are characterized by having an autoimmune background.
Determining the mechanisms underlying autoimmunity is, therefore, important to further …

A Predictive Disease Risk Model for Ankylosing Spondylitis: Based on Integrated Bioinformatic Analysis and Identification of Potential Biomarkers Most Related to …

W Gao, R Hou, Y Chen, X Wang, G Liu… - Mediators of …, 2023 - Wiley Online Library
Background. The pathogenesis of ankylosing spondylitis (AS) is still not clear, and immune‐
related genes have not been systematically explored in AS. The purpose of this paper was …

Association Study between Psoriatic Arthritis and Killer Immunoglobulin-Like Receptor (KIR) Genes: A Meta-Analysis

M Enciso-Vargas, L Alvarado-Ruíz… - Immunological …, 2021 - Taylor & Francis
ABSTRACT Background: Psoriatic Arthritis (PsA) is a seronegative spondyloarthropathy
frequently associated with psoriasis. Studies have shown different members of the KIR …

Granulysin expression increases with increasing clinical severity of psoriasis

LH Elgarhy, MM Shareef… - Clinical and Experimental …, 2015 - academic.oup.com
Background Psoriasis is an erythematosquamous dermatosis, which has strong expression
of antimicrobial peptides (AMPs), imparting a high resistance to lesional skin infection …

Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis

M Vičić, S Peternel, E Simonić, V Sotošek-Tokmadžić… - Medical hypotheses, 2016 - Elsevier
Psoriasis is a chronic papulosquamous skin disease, histologically characterized by
epidermal hyperproliferation and dermal infiltration of inflammatory cells. The majority of T …

Possible role of granulysin in pathogenesis of osteoarthritis

T Kehler, G Laskarin, D Massari, M Dominovic… - Medical hypotheses, 2015 - Elsevier
Increased presence of immune mediator and cytotoxic/apoptotic molecule granulysin was
noticed in different tissues during pathological processes with the domination of Th1 over …

颗粒溶素在某些皮肤病中的研究进展

邱小惠, 纪超, 程波 - 中国麻风皮肤病杂志, 2018 - zgmfskin.com
颗粒溶素是一种溶细胞和促炎症分子, 表达于活化的人类细胞毒T 细胞(CTLs) 和自然杀伤(NK)
细胞, 参与Stevens-Johnson 综合征/中毒性坏死性表皮松解症(SJS/TEN), 银屑病, 毛囊炎 …