The challenge and prospect of mRNA therapeutics landscape

Y Weng, C Li, T Yang, B Hu, M Zhang, S Guo… - Biotechnology …, 2020 - Elsevier
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …

Therapeutic mRNA engineering from head to tail

L Jia, SB Qian - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Synthetic messenger RNA (mRNA), once delivered into cells, can be readily
translated into proteins by ribosomes, which do not distinguish exogenous mRNAs from …

A brief review of reporter gene imaging in oncolytic virotherapy and gene therapy

SJ Russell, KW Peng - Molecular Therapy-Oncolytics, 2021 - cell.com
Reporter gene imaging (RGI) can accelerate development timelines for gene and viral
therapies by facilitating rapid and noninvasive in vivo studies to determine the …

Advances in the molecular mechanism and targeted therapy of radioactive-iodine refractory differentiated thyroid cancer

L Zhang, Z Li, M Zhang, H Zou, Y Bai, Y Liu, J Lv, L Lv… - Medical Oncology, 2023 - Springer
Most patients with differentiated thyroid cancer have a good prognosis after radioactive
iodine-131 treatment, but there are still a small number of patients who are not sensitive to …

Nevirapine increases sodium/iodide symporter-mediated radioiodide uptake by activation of TSHR/cAMP/CREB/PAX8 signaling pathway in dedifferentiated thyroid …

H Shang, J Zhao, J Yao, H Wang, J Dong… - Frontiers in …, 2020 - frontiersin.org
Nevirapine has been proved to be effective in inducing re-differentiation and suppressing
tumor growth in several tumor cells. This study aims to investigate the therapeutic potential …

Advancing immune and cell-based therapies through imaging

V Ponomarev - Molecular Imaging and Biology, 2017 - Springer
Immunotherapies include various approaches, ranging from stimulating effector
mechanisms to counteracting inhibitory and suppressive mechanisms, and creating a forum …

Non-invasive molecular imaging of immune cell dynamics for vaccine research

H Youn, KJ Hong - Clinical and Experimental Vaccine …, 2019 - synapse.koreamed.org
In order to develop a successful vaccine against deadly diseases with a wide range of
antigenic diversity, an in-depth knowledge of the molecules and signaling mechanisms …

Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS)

SC Concilio, HR Zhekova, SY Noskov, SJ Russell - PloS one, 2020 - journals.plos.org
The sodium iodide symporter (NIS) transports iodide, which is necessary for thyroid
hormone production. NIS also transports other monovalent anions such as tetrafluoroborate …

Overexpression of both human sodium iodide symporter (NIS) and BRG1-bromodomain synergistically enhances radioiodine sensitivity by stabilizing p53 through …

J Na, CH Lee, JK Chung, H Youn - International Journal of Molecular …, 2023 - mdpi.com
Improved therapeutic strategies are required to minimize side effects associated with
radioiodine gene therapy to avoid unnecessary damage to normal cells and radiation …

Smoothing membrane protein structure determination by initial upstream stage improvements

AQ Pedro, JA Queiroz, LA Passarinha - Applied microbiology and …, 2019 - Springer
Abstract Membrane proteins (MP) constitute 20–30% of all proteins encoded by the genome
of various organisms and perform a wide range of essential biological functions. However …