Microglial cells are responsible for immune surveillance within the CNS. They respond to
noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory …

Peroxisome proliferator-activated receptor (PPAR) β/δ belongs to the family of hormone and
lipid-activated nuclear receptors, which are involved in metabolism of long-chain fatty acids …

Microglia, brain cells of nonneural origin, orchestrate the inflammatory response to diverse
insults, including hypoxia/ischemia or maternal/fetal infection in the perinatal brain …

The enzyme 12/15-lipoxygenase (LOX) oxidizes various free fatty acids, including
arachidonic acid (AA). In the brain, the principal 12/15-LOX metabolites of AA are 12 (S) …

Abstract Prader‐Willi Syndrome (PWS) is a rare and incurable congenital
neurodevelopmental disorder, resulting from the absence of expression of a group of genes …

Objective Leptin is a cytokine produced by adipose tissue that acts mainly on the
hypothalamus to regulate appetite and energy homeostasis. Previous studies revealed that …

Synthetic selective modulators of the estrogen receptors (SERMs) have shown to protect
neurons and glial cells against toxic insults. Among the most relevant beneficial effects …

The development of neuropathic syndromes is an important, dose limiting side effect of
anticancer agents like platinum derivates, taxanes and vinca alkaloids. The causes of …

Obese leptin-deficient (ob/ob) mice demonstrate defects in upper airway structural and
neuromuscular control. We hypothesized that these defects predispose to upper airway …

Nonalcoholic steatohepatitis (NASH) is liver inflammation and a major threat to public
health. Several pharmaceutical agents have been used for NASH therapy but their high-rate …