[HTML][HTML] New promising therapeutic avenues of curcumin in brain diseases

T Benameur, G Giacomucci, MA Panaro, M Ruggiero… - Molecules, 2022 - mdpi.com
Curcumin, the dietary polyphenol isolated from Curcuma longa (turmeric), is commonly used
as an herb and spice worldwide. Because of its bio-pharmacological effects curcumin is also …

Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation

S Madireddy, S Madireddy - Brain sciences, 2023 - mdpi.com
Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures
that affects 50 million individuals globally. Because approximately one-third of patients with …

The role of iron, its metabolism and ferroptosis in traumatic brain injury

S Tang, P Gao, H Chen, X Zhou, Y Ou… - Frontiers in cellular …, 2020 - frontiersin.org
Traumatic brain injury (TBI) is a structural and physiological disruption of brain function
caused by external forces. It is a major cause of death and disability for patients worldwide …

[HTML][HTML] Curcumin, inflammation, and neurological disorders: How are they linked?

P Garodia, M Hegde, AB Kunnumakkara… - Integrative Medicine …, 2023 - Elsevier
Background: Despite the extensive research in recent years, the current treatment modalities
for neurological disorders are suboptimal. Curcumin, a polyphenol majorly found in …

Potentials of curcumin as an antidepressant

SK Kulkarni, A Dhir, KK Akula - The Scientific World Journal, 2009 - Wiley Online Library
Major depression, a debilitating psychiatric disorder, is predicted to be the second most
prevalent human illness by the year 2020. Various antidepressants, ranging from …

[HTML][HTML] An overview of curcumin in neurological disorders

SK Kulkarni, A Dhir - Indian journal of pharmaceutical sciences, 2010 - ncbi.nlm.nih.gov
Curcumin, the principal curcuminoid found in spice turmeric, has recently been studied for its
active role in the treatment of various central nervous system disorders. Curcumin …

Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model

J Mehla, KH Reeta, P Gupta, YK Gupta - Life sciences, 2010 - Elsevier
AIM: Epilepsy as well as chronic use of most antiepileptic drugs predisposes to cognitive
impairment. Curcumin has been reported to possess antioxidant, anticonvulsant as well as …

Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: from tuberous sclerosis to common acquired epilepsies

M Wong - Epilepsia, 2010 - Wiley Online Library
Most current treatments for epilepsy are symptomatic therapies that suppress seizures but
do not affect the underlying course or prognosis of epilepsy. The need for disease‐modifying …

Deferoxamine ameliorates neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury

H Jia, X Liu, Y Cao, H Niu, L Zhang, RJ Li, F Li, D Sun… - Brain Research, 2023 - Elsevier
Traumatic brain injury (TBI) is an important reason of neurological damage and has high
morbidity and mortality rates. The secondary damage caused by TBI leads to a poor clinical …

Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia

N Hishikawa, Y Takahashi, Y Amakusa… - AYU (An international …, 2012 - journals.lww.com
We describe here three patients with the Alzheimer's Disease (AD) whose behavioral
symptoms were improved remarkably as a result of the turmeric treatment, which is the …