TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
TRPC channels: Structure, function, regulation and recent advances in small molecular probes
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
Transient receptor potential channels: current perspectives on evolution, structure, function and nomenclature
The transient receptor potential superfamily of ion channels (TRP channels) is widely
recognized for the roles its members play in sensory nervous systems. However, the …
recognized for the roles its members play in sensory nervous systems. However, the …
Transient receptor potential canonical (TRPC) channels: then and now
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …
Membrane protein structural biology in the era of single particle cryo-EM
Y Cheng - Current opinion in structural biology, 2018 - Elsevier
In the past few years, significant technological breakthroughs in single particle cryo-electron
microscopy enabled a 'resolution revolution'of this technique. It also changed structural …
microscopy enabled a 'resolution revolution'of this technique. It also changed structural …
Sensory TRP channels in three dimensions
MM Diver, JV Lin King, D Julius… - Annual review of …, 2022 - annualreviews.org
Transient receptor potential (TRP) ion channels are sophisticated signaling machines that
detect a wide variety of environmental and physiological signals. Every cell in the body …
detect a wide variety of environmental and physiological signals. Every cell in the body …
Structural basis for pharmacological modulation of the TRPC6 channel
Transient receptor potential canonical (TRPC) proteins form nonselective cation channels
that play physiological roles in a wide variety of cells. Despite growing evidence supporting …
that play physiological roles in a wide variety of cells. Despite growing evidence supporting …
Structural mechanisms of transient receptor potential ion channels
E Cao - Journal of General Physiology, 2020 - rupress.org
Transient receptor potential (TRP) ion channels are evolutionarily ancient sensory proteins
that detect and integrate a wide range of physical and chemical stimuli. TRP channels are …
that detect and integrate a wide range of physical and chemical stimuli. TRP channels are …
Ligand-binding sites in vanilloid-subtype TRP channels
MV Yelshanskaya, AI Sobolevsky - Frontiers in Pharmacology, 2022 - frontiersin.org
Vanilloid-subfamily TRP channels TRPV1-6 play important roles in various physiological
processes and are implicated in numerous human diseases. Advances in structural biology …
processes and are implicated in numerous human diseases. Advances in structural biology …