The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration,
magnitude, and chemical nature of purinergic signals delivered to immune cells through the …

Cardiac function is required for blood circulation and systemic oxygen delivery. However,
the heart has intrinsic oxygen demands that must be met to maintain effective contractility …

In the 10 years since our previous International Union of Basic and Clinical Pharmacology
report on the nomenclature and classification of adenosine receptors, no developments …

Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …

Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the
immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent …

Highlights•CD73 is a multifunctional ectoenzyme affecting both tumor cells and immune
cells.•CD73 has been hijacked by TME to promote tumor growth and metastasis.•Targeting …

The involvement of extracellular nucleotides and adenosine in an array of cell-specific
responses has long been known and appreciated, but the integrative view of purinergic …

Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

This review focuses on the association between vascular calcification and arterial stiffness,
highlighting the important genetic factors, systemic and local microenvironmental signals …