Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
JAHR Claassen, DHJ Thijssen… - Physiological …, 2021 - journals.physiology.org
Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …
Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
[HTML][HTML] Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles
NR Tykocki, EM Boerman… - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
Role of TRP channels in the cardiovascular system
Z Yue, J Xie, AS Yu, J Stock, J Du… - American Journal of …, 2015 - journals.physiology.org
The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …
Helix 8 is the essential structural motif of mechanosensitive GPCRs
S Erdogmus, U Storch, L Danner, J Becker… - Nature …, 2019 - nature.com
G-protein coupled receptors (GPCRs) are versatile cellular sensors for chemical stimuli, but
also serve as mechanosensors involved in various (patho) physiological settings like …
also serve as mechanosensors involved in various (patho) physiological settings like …
Bone and skeletal muscle: key players in mechanotransduction and potential overlapping mechanisms
CA Goodman, TA Hornberger, AG Robling - Bone, 2015 - Elsevier
The development and maintenance of skeletal muscle and bone mass is critical for
movement, health and issues associated with the quality of life. Skeletal muscle and bone …
movement, health and issues associated with the quality of life. Skeletal muscle and bone …
In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease
BL Lin, D Matera, JF Doerner… - Proceedings of the …, 2019 - National Acad Sciences
Transient receptor potential canonical type 6 (TRPC6) is a nonselective receptor-operated
cation channel that regulates reactive fibrosis and growth signaling. Increased TRPC6 …
cation channel that regulates reactive fibrosis and growth signaling. Increased TRPC6 …
Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension
Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates
cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating …
cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating …
Vasculo-neuronal coupling: retrograde vascular communication to brain neurons
Continuous cerebral blood flow is essential for neuronal survival, but whether vascular tone
influences resting neuronal function is not known. Using a multidisciplinary approach in both …
influences resting neuronal function is not known. Using a multidisciplinary approach in both …