A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how
lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo …

There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation …

Post-translational arginine methylation is responsible for regulation of many biological
processes. The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1 …

The core histone tails are critical in chromatin structure and signaling. Studies over the past
several decades have provided a wealth of information on the histone tails and their …

Many key cellular processes can be regulated by the seemingly simple addition of one, or
two, methyl groups to arginine residues by the nine known mammalian protein arginine …

Arginine methylation is a common posttranslational modification (PTM) that alters roughly
0.5% of all arginine residues in the cells. There are three types of arginine methylation …

The mammalian protein arginine methyltransferase 7 (PRMT7) has been implicated in roles
of transcriptional regulation, DNA damage repair, RNA splicing, cell differentiation, and …

Increasing evidence suggests that PRMT 5, a protein arginine methyltransferase, is involved
in tumorigenesis. However, no systematic research has demonstrated the cell‐transforming …