The regulative role and mechanism of BNST in anxiety disorder

M Xie, Y Xiong, H Wang - Frontiers in Psychiatry, 2024 - frontiersin.org
Anxiety disorders, common yet impactful emotional disturbances, significantly affect physical
and mental health globally. Many neuron circuits are associated with anxiety regulation like …

Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs

H Zhao, Y Liu, N Cai, X Liao, L Tang… - Drug Design …, 2024 - Taylor & Francis
Over the past decade, the idea of targeting the endocannabinoid system to treat anxiety
disorders has received increasing attention. Previous studies focused more on developing …

FABP5 is important for cognitive function and is an important regulator of the physiological effects and pharmacokinetics of acute Δ9 tetrahydrocannabinol inhalation in …

SL Penman, NM Roeder, EC Berthold… - Pharmacology …, 2023 - Elsevier
Fatty acid binding protein 5 (FABP5) interacts with the endocannabinoid system in the brain
via intracellular transport of anandamide, as well as Δ9-tetrahydrocannabinol (THC), the …

Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons

OY Zhanmu, Y Yang, B Feng, H Wang, H Li… - Acta Pharmacologica …, 2024 - nature.com
Itch causes a strong urge to scratch and induces negative emotions, such as aversion and
anxiety. Antihistamine medications are key in the clinical management of pruritus, but their …

The expression of contextual fear conditioning involves the dorsal hippocampus TRPV1 receptor interacting with the NMDA/NO/cGMP signalling pathway

GL Bertacchini, AB Sonego, SF Lisboa… - British Journal of …, 2025 - Wiley Online Library
Abstract Background and Purpose The dorsal hippocampus (dHIP) is pivotal for learning,
memory, and defensive responses. Transient receptor potential vanilloid type 1 (TRPV1) …

Endocannabinoid system in the paraventricular nucleus of the hypothalamus modulates autonomic and cardiovascular changes but not vasopressin response in a rat …

C Busnardo, A Fassini, S Lopes-Azevedo… - Shock, 2023 - journals.lww.com
We evaluated the participation of the endocannabinoid system in the paraventricular
nucleus of the hypothalamus (PVN) on the cardiovascular, autonomic and plasma …