GABA-ergic cell therapy for epilepsy: Advances, limitations and challenges
Diminution in the number of gamma-amino butyric acid positive (GABA-ergic) interneurons
and their axon terminals, and/or alterations in functional inhibition are conspicuous brain …
and their axon terminals, and/or alterations in functional inhibition are conspicuous brain …
Hippocampal injury-induced cognitive and mood dysfunction, altered neurogenesis, and epilepsy: can early neural stem cell grafting intervention provide protection?
AK Shetty - Epilepsy & Behavior, 2014 - Elsevier
Damage to the hippocampus can occur through many causes including head trauma,
ischemia, stroke, status epilepticus, and Alzheimer's disease. Certain changes such as …
ischemia, stroke, status epilepticus, and Alzheimer's disease. Certain changes such as …
Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress
K Ma, A Xu, S Cui, MR Sun, YC Xue… - Translational psychiatry, 2016 - nature.com
Major depression is a prevalent emotion disorder. Chronic stressful life in genetically
susceptible individuals is presumably a major etiology that leads to neuron and synapse …
susceptible individuals is presumably a major etiology that leads to neuron and synapse …
Mood and memory deficits in a model of Gulf War illness are linked with reduced neurogenesis, partial neuron loss, and mild inflammation in the hippocampus
VK Parihar, B Hattiangady, B Shuai… - …, 2013 - nature.com
Impairments in mood and cognitive function are the key brain abnormalities observed in Gulf
war illness (GWI), a chronic multisymptom health problem afflicting∼ 25% of veterans who …
war illness (GWI), a chronic multisymptom health problem afflicting∼ 25% of veterans who …
Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy
Nearly 30% of patients with mesial temporal lobe epilepsy (TLE) are resistant to treatment
with antiepileptic drugs. Neural stem cell (NSC) grafting into the hippocampus could offer an …
with antiepileptic drugs. Neural stem cell (NSC) grafting into the hippocampus could offer an …
GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury
CP Almeida-Suhett, EM Prager, V Pidoplichko… - Experimental …, 2015 - Elsevier
Patients that suffer mild traumatic brain injuries (mTBI) often develop cognitive impairments,
including memory and learning deficits. The hippocampus shows a high susceptibility to …
including memory and learning deficits. The hippocampus shows a high susceptibility to …
Traumatic brain injury precipitates cognitive impairment and extracellular Aβ aggregation in Alzheimer's disease transgenic mice
N Tajiri, SL Kellogg, T Shimizu, GW Arendash… - PloS one, 2013 - journals.plos.org
Traumatic brain injury (TBI) has become a signature wound of the wars in Iraq and
Afghanistan. Many American soldiers, even those undiagnosed but likely suffering from mild …
Afghanistan. Many American soldiers, even those undiagnosed but likely suffering from mild …
Potential of GABA-ergic cell therapy for schizophrenia, neuropathic pain, and Alzheimer׳ s and Parkinson׳ s diseases
AK Shetty, A Bates - Brain research, 2016 - Elsevier
Several neurological and psychiatric disorders present hyperexcitability of neurons in
specific regions of the brain or spinal cord, partly because of some loss and/or dysfunction of …
specific regions of the brain or spinal cord, partly because of some loss and/or dysfunction of …
Differential susceptibility of interneurons expressing neuropeptide Y or parvalbumin in the aged hippocampus to acute seizure activity
Acute seizure (AS) activity in old age has an increased predisposition for evolving into
temporal lobe epilepsy (TLE). Furthermore, spontaneous seizures and cognitive dysfunction …
temporal lobe epilepsy (TLE). Furthermore, spontaneous seizures and cognitive dysfunction …
Promise of resveratrol for easing status epilepticus and epilepsy
AK Shetty - Pharmacology & therapeutics, 2011 - Elsevier
Resveratrol (RESV; 3, 5, 4′-tri-hydroxy stilbene), a naturally occurring phytoalexin, is found
at a high concentration in the skin of red grapes and red wine. RESV mediates a wide-range …
at a high concentration in the skin of red grapes and red wine. RESV mediates a wide-range …