Advancing therapy for neuroblastoma
B Qiu, KK Matthay - Nature Reviews Clinical Oncology, 2022 - nature.com
Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …
ranging from localized or spontaneously regressing to widely metastatic disease …
[HTML][HTML] Recent advances in the developmental origin of neuroblastoma: an overview
M Ponzoni, T Bachetti, MV Corrias, C Brignole… - Journal of Experimental …, 2022 - Springer
Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …
undergoing a defective differentiation due to genomic and epigenetic impairments …
[HTML][HTML] RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
The majority of oncogenic drivers are intracellular proteins, thus constraining their
immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual …
immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual …
[HTML][HTML] Histone deacetylases (HDACs): evolution, specificity, role in transcriptional complexes, and pharmacological actionability
G Milazzo, D Mercatelli, G Di Muzio, L Triboli… - Genes, 2020 - mdpi.com
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …
removing acetyl groups from histones and other protein regulatory factors, with functional …
[HTML][HTML] Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene
copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA) …
copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA) …
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
Gene expression is regulated by promoters and enhancers marked by histone H3 lysine 27
acetylation (H3K27ac), which is established by the paralogous histone acetyltransferases …
acetylation (H3K27ac), which is established by the paralogous histone acetyltransferases …
A first-generation pediatric cancer dependency map
Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-
burden adult cancers. A key question, however, is whether functional genomic approaches …
burden adult cancers. A key question, however, is whether functional genomic approaches …
[HTML][HTML] MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma
Y Lu, Q Yang, Y Su, Y Ji, G Li, X Yang, L Xu, Z Lu… - Cell death & …, 2021 - nature.com
MYCN amplification is tightly associated with the poor prognosis of pediatric neuroblastoma
(NB). The regulation of NB cell death by MYCN represents an important aspect, as it directly …
(NB). The regulation of NB cell death by MYCN represents an important aspect, as it directly …
Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes
Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited
success due to immune evasion mechanisms, coupled with an incomplete understanding of …
success due to immune evasion mechanisms, coupled with an incomplete understanding of …
Super enhancers define regulatory subtypes and cell identity in neuroblastoma
M Gartlgruber, AK Sharma, A Quintero, D Dreidax… - Nature Cancer, 2021 - nature.com
Half of the children diagnosed with neuroblastoma (NB) have high-risk disease,
disproportionately contributing to overall childhood cancer-related deaths. In addition to …
disproportionately contributing to overall childhood cancer-related deaths. In addition to …