The need to identify effective therapies for the treatment of psychiatric disorders is a
particularly important issue in modern societies. In addition, difficulties in finding new drugs …

Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

The pathogenesis of Alzheimer's disease (AD), the most prevalent form of dementia,
remains unclear. Over the past few years, evidence has accumulated indicating that …

Brain tissue metabolism is distributed across several cell types and subcellular
compartments, which activate at different times and with different temporal patterns. The …

The study of metabolism is undergoing a renaissance. Since the year 2002, over 50
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …

The mitochondrial anchor syntaphilin (SNPH) is a key mitochondrial protein normally
expressed in axons to maintain neuronal health by positioning mitochondria along axons for …

Mitochondria are a crucial energy source for maintaining neuronal growth and synaptic
function. Neurons possess unique morphological characteristics, which make the proper …

Sensorineural hearing loss (SNHL) is a category of hearing loss that often leads to difficulty
in understanding speech and other sounds. Auditory system dysfunction, including deafness …

In vertebrates, a high density of voltage-gated Na+ channel at nodes of Ranvier and of
voltage-gated K+ channel at juxtaparanodes is necessary for rapid propagation of action …

Dysfunction in mitochondrial maintenance and trafficking is commonly correlated with the
development of neurodegenerative disorders such as Parkinson's disease and Alzheimer's …