In recent years, much interest has been devoted to defining the role of the IGF system in the
nervous system. The ubiquitous IGFs, their cell membrane receptors, and their carrier …

Recent evidence suggests that neurotrophic factors that promote the survival or
differentiation of developing neurons may also protect mature neurons from neuronal …

Newborn mice homozygous for a targeted disruption of insulin-like growth factor gene 1 (Igf-
1) exhibit a growth deficiency similar in severity to that prevlously observed in viable Igf-2 …

The somatomedin hypothesis proposed that insulin-like growth factor I (IGF-I) was a
hepatically derived circulating mediator of growth hormone and is a crucial factor for …

Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in
multiple aspects of growth, development and metabolism. The biological actions of IGF1 are …

Abstract" The insulin-like growth factors (IGF-I and IGF-II) are single-chain polypeptides with
structural homology to proinsulin. They regulate proliferation and differentiation of a …

Genetic analyses of dwarfing phenotypes resulting from targeted mutagenesis of the genes
encoding the insulin-like growth factors (IGF-I and IGF-II) and their cognate type 1 IGF …

The following brief summary is based on a recent wx review by Rubin and Baserga 1, and
the reader is referred to that review for extended references. A simplified representation of …

The insulin-like growth factor I receptor (IGF-IR) plays a critical role in transformation events.
It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic …

Insulin-like growth factors have a number of potent trophic effects on cultured neurat tissue
and most if not all of these effects appear to be mediated by the type-I insulin-like growth …