Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Super-resolution microscopy has overcome a long-held resolution barrier—the diffraction
limit—in light microscopy and enabled visualization of previously invisible molecular details …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …

In 1986, electron microscopy was used to reconstruct by hand the entire nervous system of a
roundworm, the nematode Caenorhabditis elegans. Since this landmark study, high …

Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …

Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …

Proteins critical for synaptic transmission are non-uniformly distributed and assembled into
regions of high density called subsynaptic densities (SSDs) that transsynaptically align in …

Many crowded biomolecular structures in cells and tissues are inaccessible to labelling
antibodies. To understand how proteins within these structures are arranged with nanoscale …

AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …