Viruses of archaea represent one of the most enigmatic parts of the virosphere. Most of the
characterized archaeal viruses infect extremophilic hosts and display remarkable diversity of …

Prokaryotes, bacteria and archaea, are the most abundant cellular organisms among those
sharing the planet Earth with human beings (among others). However, numerous ecological …

The CRISPR system in bacteria and archaea provides adaptive immunity against mobile
genetic elements. Type III CRISPR systems detect viral RNA, resulting in the activation of …

This review presents a personal account of research on archaeal viruses and describes
many new viral species and families, demonstrating that viruses of Archaea constitute a …

We prove that proteins with nontrivial topology, containing knots and slipknots, have the
ability to fold to their native states without any additional external forces invoked. Our studies …

Viruses populate virtually every ecosystem on the planet, including the extreme acidic,
thermal, and saline environments where archaeal organisms can dominate. For example …

Among the thousands of known three-dimensional protein folds, only a few have been found
whose backbones are in knotted configurations. The rarity of knotted proteins has important …

Background Archaeal and bacterial genomes contain a number of genes of foreign origin
that arose from recent horizontal gene transfer, but the role of integrative elements (IEs) …

The Archaea—and their viruses—remain the most enigmatic of life's three domains. Once
thought to inhabit only extreme environments, archaea are now known to inhabit diverse …

Protein structure is highly diverse when considering a wide range of protein types, helping to
give rise to the multitude of functions that proteins perform. In particular, certain proteins are …