Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Mitochondria play a critical role in maintaining cellular function by ATP production. They are
also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of …

Stimulation of mitochondrial oxidative metabolism by Ca2+ is now generally recognised as
important for the control of cellular ATP homeostasis. Here, we review the mechanisms …

Cyclophilin D (CyPD) is an important mitochondrial chaperone protein whose mechanism of
action remains a mystery. It is well known for regulating mitochondrial function and coupling …

The energy starvation hypothesis proposes that maladaptive metabolic remodeling
antedates, initiates, and maintains adverse contractile dysfunction in heart failure (HF) …

There is an increasing body of evidence for local circuits of ATP generation and
consumption that are largely independent of global cellular ATP levels. These are mostly …

Mitochondrial electron transport is essential for oxidative phosphorylation (OXPHOS).
Electron transport chain (ETC) activity generates an electrochemical gradient that is used by …

Elucidation of the mitochondrial regulatory mechanisms for the understanding of muscle
bioenergetics and the role of mitochondria is a fundamental problem in cellular physiology …

Microphysiological systems (MPS) are drawing increasing interest from academia and from
biomedical industry due to their improved capability to capture human physiology. MPS offer …

This review describes the recent experimental data on the importance of the VDAC–
cytoskeleton interactions in determining the mechanisms of energy and metabolite transfer …