With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid,
finely granulated, digital health measures are highly warranted to augment clinical and …

Significant advancements have been achieved in delineating the progress of the Global
PROMS (PROMS) Initiative. The PROMS Initiative, a collaborative endeavor by the …

This study aimed to validate a wearable device's walking speed estimation pipeline,
considering complexity, speed, and walking bout duration. The goal was to provide …

Inhibitors of monoamine oxidase B (MAO-B) and catechol-O-methyltransferase (COMT) are
major strategies to reduce levodopa degradation and thus to increase and prolong its effect …

Background Real‐world monitoring using wearable sensors has enormous potential for
assessing disease severity and symptoms among persons with Parkinson's disease (PD) …

The loss of mobility is a common trait in multiple health conditions (eg, Parkinson's disease)
and is associated with reduced quality of life. In this context, being able to monitor mobility in …

Background Gait variables assessed by inertial measurement units (IMUs) show promise as
screening tools for aging-related diseases like sarcopenia. The main aims of this systematic …

Background: Digital measures offer an unparalleled opportunity to create a more holistic
picture of how people who are patients behave in their real-world environments, thereby …

Alzheimer's disease (AD) and other neurodegenerative diseases such as Parkinson's
disease (PD) and Huntington's disease (HD) are associated with progressive cognitive …

Mobility is often referred to as a 'sixth vital sign'because of its ability to predict critical health
outcomes in later adulthood. In the World Health Organization (WHO) World Report on …