Hypervalent aryliodoumiums are intensively investigated as arylating agents. They are
excellent surrogates to aryl halides, and moreover they exhibit better reactivity, which allows …

The nitrogen–nitrogen bond is a core feature of diverse functional groups like hydrazines,
nitrosamines, diazos, and pyrazoles. Such functional groups are found in> 300 known …

Levocetirizine is an orally administrated, second‐generation antihistaminic active
pharmaceutical ingredient that has been used to treat symptoms of allergy and long‐term …

3D electron diffraction (3D ED)/Micro electron diffraction (MicroED) has extended the limits
of crystallography by enabling the determination of three dimensional molecular structures …

Electron crystallography has a storied history which rivals that of its more established X-ray-
enabled counterpart. Recent advances in data collection and analysis have sparked a …

Natural products (NPs) historically serve as a valuable and productive source of bioactive
compounds for drug development. The discovery of a range of alkaloids in the early 1800s …

Angucyclines are type II polyketide natural products, often characterized by unusual
structural rearrangements through B-or C-ring cleavage of their tetracyclic backbone. While …

Conspectus Analytical methods allow for the structure determination of submilligram
quantities of complex secondary metabolites. This has been driven in large part by …

Micromonospora, one of the most important actinomycetes genera, is well-known as the
treasure trove of bioactive secondary metabolites (SMs). Herein, together with an in-depth …

Epoxide ring opening reactions are common and important in both biological processes and
synthetic applications and can be catalyzed in a non-redox manner by epoxide hydrolases …