Advancements and challenges in mRNA and ribonucleoprotein-based therapies: From delivery systems to clinical applications

Z Eftekhari, H Zohrabi, A Oghalaie, T Ebrahimi… - … Therapy-Nucleic Acids, 2024 - cell.com
The use of mRNA and ribonucleoproteins (RNPs) as therapeutic agents is a promising
strategy for treating diseases like cancer and infectious diseases. This review provides …

Advances on delivery system of active ingredients of dried toad skin and toad venom

D Zhang, B Zhai, J Sun, J Cheng… - International journal of …, 2024 - Taylor & Francis
Dried toad skin (TS) and toad venom (TV) are the dried skin of the Bufo bufo gargarizans
Cantor and the Bufo melanostictus Schneider, which remove the internal organs and the …

[HTML][HTML] Nanoparticle-based drug delivery systems in inhaled therapy: improving respiratory medicine

E Cojocaru, OR Petriș, C Cojocaru - Pharmaceuticals, 2024 - mdpi.com
Inhaled nanoparticle (NP) therapy poses intricate challenges in clinical and
pharmacodynamic realms. Recent strides have revolutionized NP technology by enabling …

Nanomaterial mediated genome engineering for sustainable food production: Current status and future prospects

A Tandon, A Singh, A Thakur, V Sharma - Biocatalysis and Agricultural …, 2023 - Elsevier
Nanotechnology finds diverse applications in various fields including agriculture to increase
food production as well as alleviate biotic and abiotic stress. Due to their unique …

Recent advances in mesoporous silica nanoparticles delivering siRNA for cancer treatment

X Xie, T Yue, W Gu, WY Cheng, L He, WY Ren, F Li… - Pharmaceutics, 2023 - mdpi.com
Silencing genes using small interfering (si) RNA is a promising strategy for treating cancer.
However, the curative effect of siRNA is severely constrained by low serum stability and cell …

Clinical Insights into MicroRNAs in Depression: Bridging Molecular Discoveries and Therapeutic Potential

L Kaurani - International Journal of Molecular Sciences, 2024 - mdpi.com
Depression is a major contributor to the overall global burden of disease. The discovery of
biomarkers for diagnosis or prediction of treatment responses and as therapeutic agents is a …

Engineered Silica Nanoparticles for Nucleic Acid Delivery

Y Zhang, Y Yu, Y Yang, Y Wang, C Yu - Small Methods, 2024 - Wiley Online Library
The development of nucleic acid‐based drugs holds great promise for therapeutic
applications, but their effective delivery into cells is hindered by poor cellular membrane …

[HTML][HTML] RNA Structure: Past, Future, and Gene Therapy Applications

WA Haseltine, K Hazel, R Patarca - International Journal of Molecular …, 2024 - mdpi.com
First believed to be a simple intermediary between the information encoded in
deoxyribonucleic acid and that functionally displayed in proteins, ribonucleic acid (RNA) is …

Preliminary anticancer activity of Carpobrotus edulis (L.) Bolus exposed to low and high temperature conditions against cervical cancer

M Mashigo, K Ngwira, I Risenga… - Journal of Herbmed …, 2024 - herbmedpharmacol.com
Introduction: Environmental temperature conditions might influence the composition of
secondary metabolites in certain medicinal plants. This study aimed to examine how some …

Nanoparticles for Cancer Gene Therapy and Imaging

DA Fernandes - Biomedical Materials & Devices, 2024 - Springer
Gene therapy has shown to be a promising strategy for the treatment of cancer through the
alteration of gene expression. A main part of its success has been the efficient delivery of …