Activation of paramyxovirus membrane fusion and virus entry

TS Jardetzky, RA Lamb - Current opinion in virology, 2014 - Elsevier
Highlights•Most paramyxoviruses require attachment and fusion (F) proteins for cell
entry.•Competing 'clamp'and 'provocateur'models have been proposed as entry …

Measles virus fusion protein: structure, function and inhibition

P Plattet, L Alves, M Herren, HC Aguilar - Viruses, 2016 - mdpi.com
Measles virus (MeV), a highly contagious member of the Paramyxoviridae family, causes
measles in humans. The Paramyxoviridae family of negative single-stranded enveloped …

Receptor-mediated cell entry of paramyxoviruses: Mechanisms, and consequences for tropism and pathogenesis

CK Navaratnarajah, AR Generous, I Yousaf… - Journal of Biological …, 2020 - ASBMB
Research in the last decade has uncovered many new paramyxoviruses, airborne agents
that cause epidemic diseases in animals including humans. Most paramyxoviruses enter …

Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies

NV Johnson, RC van Scherpenzeel… - Nature …, 2024 - nature.com
Respirovirus 3 is a leading cause of severe acute respiratory infections in vulnerable human
populations. Entry into host cells is facilitated by the attachment glycoprotein and the fusion …

Structures of Langya virus fusion protein ectodomain in pre-and postfusion conformation

AJ May, KR Pothula, K Janowska, P Acharya - Journal of virology, 2023 - Am Soc Microbiol
Langya virus (LayV) is a paramyxovirus in the Henipavirus genus, closely related to the
deadly Nipah (NiV) and Hendra (HeV) viruses, that was identified in August 2022 through …

[HTML][HTML] Timing is everything: Fine-tuned molecular machines orchestrate paramyxovirus entry

S Bose, TS Jardetzky, RA Lamb - Virology, 2015 - Elsevier
The Paramyxoviridae include some of the great and ubiquitous disease-causing viruses of
humans and animals. In most paramyxoviruses, two viral membrane glycoproteins, fusion …

Crystal structure of the pre-fusion Nipah virus fusion glycoprotein reveals a novel hexamer-of-trimers assembly

K Xu, YP Chan, B Bradel-Tretheway… - PLoS …, 2015 - journals.plos.org
Nipah virus (NiV) is a paramyxovirus that infects host cells through the coordinated efforts of
two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the …

Structure and stabilization of the Hendra virus F glycoprotein in its prefusion form

JJW Wong, RG Paterson, RA Lamb… - Proceedings of the …, 2016 - National Acad Sciences
Hendra virus (HeV) is one of the two prototypical members of the Henipavirus genus of
paramyxoviruses, which are designated biosafety level 4 (BSL-4) organisms due to the high …

[HTML][HTML] Impact of respiratory syncytial virus infection on host functions: implications for antiviral strategies

MJ Hu, MA Bogoyevitch, DA Jans - Physiological reviews, 2020 - journals.physiology.org
Respiratory syncytial virus (RSV) is one of the leading causes of viral respiratory tract
infection in infants, the elderly, and the immunocompromised worldwide, causing more …

Differential Features of Fusion Activation within the Paramyxoviridae

KD Azarm, B Lee - Viruses, 2020 - mdpi.com
Paramyxovirus (PMV) entry requires the coordinated action of two envelope glycoproteins,
the receptor binding protein (RBP) and fusion protein (F). The sequence of events that …