Unveiling piperazine-quinoline hybrids as potential multi-target directed anti-Alzheimer's agents: design, synthesis and biological evaluation

A Nagani, M Shah, S Patel, H Patel, V Parikh, A Patel… - Molecular Diversity, 2024 - Springer
Multi-target directed ligands (MTDLs) have recently been popularized due to their
outstanding efficacy in combating the complicated features of Alzheimer's disease. This …

Diet, pace of biological aging, and risk of dementia in the Framingham Heart Study

A Thomas, CP Ryan, A Caspi, Z Liu… - Annals of …, 2024 - Wiley Online Library
Objective People who eat healthier diets are less likely to develop dementia, but the
biological mechanism of this protection is not well understood. We tested the hypothesis that …

Induced-hyperandrogenism in female rats: assessing possible modulation of neurobehavioural and neurotransmitter changes following clomiphene/letrozole …

OJ Onaolapo, OO Aworinde, AT Olofinnade… - bioRxiv, 2023 - biorxiv.org
Hyperandrogenism is the excessive production of androgenic hormones resulting in
infertility in a number of women. While letrozole and clomiphene citrate have been used to …

Антиоксидантная активность триметоксизамещенных монокарбонильных аналогов куркумина в условиях экспериментальной болезни Альцгеймера у крыс …

ДИ Поздняков, АА Вихорь - Сибирский журнал клинической и …, 2024 - sibjcem.ru
Аннотация Введение. Болезнь Альцгеймера (БА)–терминальная форма деменции,
лечение которой представляет собой значимую медицинскую проблему, что требует …