F Giron, A Pastó, E Tasciotti… - Inflammatory bowel …, 2019 - academic.oup.com
Due to the lack of cure for inflammatory bowel disease (IBD) and failure of current medical therapies in many patients with IBD, a need exists in finding novel ways to treat inflammation …
Drug development is an expensive and time-consuming process; these could be reduced if the existing resources could be used to identify candidates for drug repurposing. This study …
L He, J Liu, S Li, X Feng, C Wang… - Advanced …, 2019 - Wiley Online Library
Prostate cancer (PCa) is the most common male urogenital malignancy worldwide. Surgery, endocrine therapy, radiotherapy, and chemotherapy are the main clinical management …
M Archibald, T Pritchard, H Nehoff… - International journal …, 2016 - Taylor & Francis
Castrate-resistant prostate cancer (CRPC) remains incurable due to the lack of effective therapies. Several tyrosine kinases have been implicated in the development and growth of …
VK Lakshmanan - Investigative and clinical urology, 2016 - synapse.koreamed.org
Recent advances in cancer nanomedicine have attracted remarkable attention in medical sectors. Pharmacologic research on nanomedicines, including targeted cancer therapy, has …
K Greish, H Nehoff, F Bahman, T Pritchard… - Journal of Drug …, 2019 - Taylor & Francis
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that differs in progression, recurrence, and prognosis from other forms of breast cancer. The …
NN Parayath, H Nehoff, SE Norton… - International Journal …, 2016 - Taylor & Francis
Oral administration of paclitaxel (PTX), a broad spectrum anticancer agent, is challenged by its low uptake due to its poor bioavailability, efflux through P-glycoprotein, and …
T Pritchard, RJ Rosengren, K Greish… - Journal of Drug …, 2016 - Taylor & Francis
Background: Castrate-resistant prostate cancer (CRPC) patients are characterised by a 5- year relative survival rate of∼ 25–33%. Recently, our laboratory encapsulated a selective …
S Xian, NN Parayath, H Nehoff, NM Giles… - Anticancer …, 2015 - ar.iiarjournals.org
Synthetic cannabinoid WIN55, 212-2 (WIN) has shown a promise as an anticancer agent but causes psychoactive side-effects. In the present study, nano-micelles of styrene maleic acid …