Kinetics of Nanomedicine in Tumor Spheroid as an In Vitro Model System for Efficient Tumor-Targeted Drug Delivery With Insights From Mathematical Models

SM Roy, V Garg, S Barman, C Ghosh… - … in Bioengineering and …, 2021 - frontiersin.org
Numerous strategies have been developed to treat cancer conventionally. Most importantly,
chemotherapy shows its huge promise as a better treatment modality over others …

Nanotechnology in the treatment of inflammatory bowel disease

F Giron, A Pastó, E Tasciotti… - Inflammatory bowel …, 2019 - academic.oup.com
Due to the lack of cure for inflammatory bowel disease (IBD) and failure of current medical
therapies in many patients with IBD, a need exists in finding novel ways to treat inflammation …

Literature-based discovery of new candidates for drug repurposing

HT Yang, JH Ju, YT Wong, I Shmulevich… - Briefings in …, 2017 - academic.oup.com
Drug development is an expensive and time-consuming process; these could be reduced if
the existing resources could be used to identify candidates for drug repurposing. This study …

Polymer nanoplatforms at work in prostate cancer therapy

L He, J Liu, S Li, X Feng, C Wang… - Advanced …, 2019 - Wiley Online Library
Prostate cancer (PCa) is the most common male urogenital malignancy worldwide. Surgery,
endocrine therapy, radiotherapy, and chemotherapy are the main clinical management …

A combination of sorafenib and nilotinib reduces the growth of castrate-resistant prostate cancer

M Archibald, T Pritchard, H Nehoff… - International journal …, 2016 - Taylor & Francis
Castrate-resistant prostate cancer (CRPC) remains incurable due to the lack of effective
therapies. Several tyrosine kinases have been implicated in the development and growth of …

Therapeutic efficacy of nanomedicines for prostate cancer: An update

VK Lakshmanan - Investigative and clinical urology, 2016 - synapse.koreamed.org
Recent advances in cancer nanomedicine have attracted remarkable attention in medical
sectors. Pharmacologic research on nanomedicines, including targeted cancer therapy, has …

Raloxifene nano-micelles effect on triple-negative breast cancer is mediated through estrogen receptor-β and epidermal growth factor receptor

K Greish, H Nehoff, F Bahman, T Pritchard… - Journal of Drug …, 2019 - Taylor & Francis
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that differs
in progression, recurrence, and prognosis from other forms of breast cancer. The …

Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model

NN Parayath, H Nehoff, SE Norton… - International Journal …, 2016 - Taylor & Francis
Oral administration of paclitaxel (PTX), a broad spectrum anticancer agent, is challenged by
its low uptake due to its poor bioavailability, efflux through P-glycoprotein, and …

Raloxifene nanomicelles reduce the growth of castrate-resistant prostate cancer

T Pritchard, RJ Rosengren, K Greish… - Journal of Drug …, 2016 - Taylor & Francis
Background: Castrate-resistant prostate cancer (CRPC) patients are characterised by a 5-
year relative survival rate of∼ 25–33%. Recently, our laboratory encapsulated a selective …

The use of styrene maleic acid nanomicelles encapsulating the synthetic cannabinoid analog WIN55, 212-2 for the treatment of cancer

S Xian, NN Parayath, H Nehoff, NM Giles… - Anticancer …, 2015 - ar.iiarjournals.org
Synthetic cannabinoid WIN55, 212-2 (WIN) has shown a promise as an anticancer agent but
causes psychoactive side-effects. In the present study, nano-micelles of styrene maleic acid …