Since its discovery as a CDKI (cyclin-dependent kinase inhibitor) in 1993, the tumor
suppressor p16 (INK4A/MTS-1/CDKN2A) has gained widespread importance in cancer. The …

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and
genome instability. This review summarizes current knowledge regarding aberrations …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

The cell cycle inhibitor p16 INK4a is inactivated in many human tumors and in families with
hereditary melanoma and pancreatic cancer. Tumor-associated alterations in the INK4a …

In late 1993 and early 1994, two distinct lines of research converged on a new tumor
suppressor gene located on human chromosome 9p21. The órst report was of the existence …

Urothelial carcinoma of the bladder is unique among epithelial carcinomas in its divergent
pathways of tumorigenesis. Low-grade papillary tumours rarely become muscle-invasive …

Since its discovery as an inhibitor of cyclin-dependent kinases 4 and 6, the tumor
suppressor p16 has continued to gain widespread importance in cancer. The high frequency …

The last fifteen years have seen an explosive progress in our knowledge of how cell
proliferation and differentiation are regulated by extracellular factors. A few growth factors …

Purpose: We determine the relative sensitivities of cytology and fluorescence in situ
hybridization (FISH) for the detection of urothelial carcinoma. Materials and Methods: A …

The purpose of this study was to develop a multitarget, multicolor fluorescence in situ
hybridization (FISH) assay for the detection of urothelial carcinoma (UC) in urine specimens …