Mathematical models for immunology: current state of the art and future research directions

R Eftimie, JJ Gillard, DA Cantrell - Bulletin of mathematical biology, 2016 - Springer
The advances in genetics and biochemistry that have taken place over the last 10 years led
to significant advances in experimental and clinical immunology. In turn, this has led to the …

Hyperbolic and kinetic models for self-organized biological aggregations and movement: a brief review

R Eftimie - Journal of mathematical biology, 2012 - Springer
We briefly review hyperbolic and kinetic models for self-organized biological aggregations
and traffic-like movement. We begin with the simplest models described by an advection …

IL-33 restricts tumor growth and inhibits pulmonary metastasis in melanoma-bearing mice through eosinophils

V Lucarini, G Ziccheddu, I Macchia, V La Sorsa… - …, 2017 - Taylor & Francis
The alarmin IL-33 is an IL-1 family member that stimulates pleiotropic immune reactions
depending on the target tissue and microenvironmental factors. In this study, we have …

The re-polarisation of M2 and M1 macrophages and its role on cancer outcomes

NY den Breems, R Eftimie - Journal of theoretical biology, 2016 - Elsevier
The anti-tumour and pro-tumour roles of Th1/Th2 immune cells and M1/M2 macrophages
have been documented by numerous experimental studies. However, it is still unknown how …

Mathematical Modelling for the Role of CD4+T Cells in Tumor‐Immune Interactions

AM Makhlouf, L El-Shennawy… - … methods in medicine, 2020 - Wiley Online Library
Mathematical modelling has been used to study tumor‐immune cell interaction. Some
models were proposed to examine the effect of circulating lymphocytes, natural killer cells …

Cellular and population plasticity of helper CD4+ T cell responses

G Magombedze, PBJ Reddy, S Eda… - Frontiers in …, 2013 - frontiersin.org
Vertebrates are constantly exposed to pathogens, and the adaptive immunity has most likely
evolved to control and clear such infectious agents. CD4+ T cells are the major players in …

Tumour-associated macrophages and oncolytic virotherapies: a mathematical investigation into a complex dynamics

R Eftimie, G Eftimie - Letters in Biomathematics, 2018 - discovery.dundee.ac.uk
Anti-cancer therapies based on oncolytic viruses are emerging as important approaches in
cancer treatment. However, the effectiveness of these therapies depends significantly on the …

Effect of ginseng polysaccharides and dendritic cells on the balance of Th1/Th2 T helper cells in patients with non-small cell lung cancer

J Ma, H Liu, X Wang - Journal of Traditional Chinese Medicine, 2014 - Elsevier
Objective To investigate the effect of thorascopic administration of ginseng polysaccharides
(GPS) plus dendritic cells (DC) on T helper cell type 1/T helper cell type 2 (Th1/Th2) balance …

Competition for antigen between Th1 and Th2 responses determines the timing of the immune response switch during Mycobaterium avium subspecies …

G Magombedze, S Eda… - PLoS computational …, 2014 - journals.plos.org
Johne's disease (JD), a persistent and slow progressing infection of ruminants such as cows
and sheep, is caused by slow replicating bacilli Mycobacterium avium subspecies …

Safety, immune and clinical responses in metastatic melanoma patients vaccinated with a long peptide derived from indoleamine 2, 3-dioxygenase in combination …

J Bjoern, TZ Iversen, NJ Nitschke, MH Andersen… - Cytotherapy, 2016 - Elsevier
Abstract Background aim Indoleamine 2, 3-dioxygenase (IDO) is an emerging new target in
cancer therapy that can be targeted with active immunotherapy (eg through peptide …