Biomarkers of mercury toxicity: Past, present, and future trends

V Branco, S Caito, M Farina… - Journal of Toxicology …, 2017 - Taylor & Francis
Mercury (Hg) toxicity continues to represent a global health concern. Given that human
populations are mostly exposed to low chronic levels of mercurial compounds …

S-mercuration of cellular proteins by methylmercury and its toxicological implications

H Kanda, Y Shinkai, Y Kumagai - The Journal of Toxicological …, 2014 - jstage.jst.go.jp
The accumulation of methylmercury (MeHg) through the daily consumption of large
predatory fish poses potential health risks. MeHg has been found to cause Minamata …

Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells

S Takeda, H Okazaki, E Ikeda, S Abe… - The Journal of …, 2014 - jstage.jst.go.jp
Metastases are known to be responsible for approximately 90% of breast cancer-related
deaths. Cyclooxygenase-2 (COX-2) is involved not only in inflammatory processes, but also …

Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury

S Penglase, K Hamre, S Ellingsen - Free Radical Biology and Medicine, 2014 - Elsevier
Selenium (Se) is an essential nutrient required by Se-dependent proteins, termed
selenoproteins. The selenoprotein family is small but diverse and includes key proteins in …

Bee venom Apis mellifera lamarckii rescues blood brain barrier damage and neurobehavioral changes induced by methyl mercury via regulating tight junction …

EH Abu-Zeid, BA Khalifa, YHA Elewa, AH Arisha… - Food and Chemical …, 2021 - Elsevier
The objective of the current study is to investigate the protective effect of Egyptian bee
venom (BV) against methyl mercury chloride (MMC) induced blood-brain barrier (BBB) …

Methylmercury toxic mechanism related to protein degradation and chemokine transcription

JY Lee, GW Hwang, A Naganuma, M Satoh - Environmental Health and …, 2020 - Springer
Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have
reported that the ubiquitin-proteasome system is involved in defense against methylmercury …

Mechanisms and modifiers of methylmercury-induced neurotoxicity

SJB Fretham, S Caito, EJ Martinez-Finley… - Toxicology …, 2012 - academic.oup.com
The neurotoxic consequences of methylmercury (MeHg) exposure have long been known,
however a complete understanding of the mechanisms underlying this toxicity is elusive …

The chemokine CCL2 protects against methylmercury neurotoxicity

D Godefroy, RD Gosselin, A Yasutake… - Toxicological …, 2012 - academic.oup.com
Industrial pollution due to heavy metals such as mercury is a major concern for the
environment and public health. Mercury, in particular methylmercury (MeHg), primarily …

Activation of interleukin‐6 and‐8 expressions by methylmercury in human U937 macrophages involves RelA and p50

M Yamamoto, N Khan, M Muniroh… - Journal of Applied …, 2017 - Wiley Online Library
The accumulation of macrophages has been observed around lesions of the brain in
patients with Minamata disease. In this condition, mercury has been detected …

Methylmercury induces CCL2 expression through activation of NF-κB in human 1321N1 astrocytes

MS Kim, T Takahashi, JY Lee, GW Hwang… - The Journal of …, 2012 - jstage.jst.go.jp
Methylmercury is an environmental pollutant that is toxic to the central nervous system;
however, the molecular mechanisms underlying its toxicity remain unclear. Methylmercury …